Volume : 13, Issue : 04, April – 2026

Title:

FORMULATION AND CHARACTERIZATION OF CANNABIDIOL SUSTAINED RELEASE BLEND MICROSPHERES

Authors :

Shivam Gaur, Satkar Prasad

Abstract :

The present study aimed to formulate and characterize sustained release blend microspheres of cannabidiol using the solvent evaporation technique. Cannabidiol, a poorly water-soluble drug with low bioavailability, requires an effective delivery system to achieve prolonged therapeutic action. In this study, microspheres were prepared using different ratios of hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC), and guar gum to evaluate their influence on drug release and formulation characteristics. A total of six formulations (F1–F6) were developed and evaluated for percentage yield, drug entrapment efficiency, buoyancy, particle size, zeta potential, and in-vitro drug release. The percentage yield ranged from 72.85% to 82.94%, while drug entrapment efficiency varied between 69.85% and 81.36%. Among all formulations, F5 exhibited the highest yield (82.94%) and entrapment efficiency (81.36%), along with superior buoyancy (81.15%) and shortest floating lag time (50 seconds). The optimized formulation showed uniform particle size distribution and good stability as confirmed by zeta potential analysis. In-vitro drug release studies demonstrated sustained release of cannabidiol over 12 hours, with formulation F5 releasing 98.85% of the drug. Release kinetics indicated that the formulation followed zero-order and Korsmeyer–Peppas models, suggesting a non-Fickian diffusion mechanism. Stability studies confirmed that the optimized formulation remained stable under accelerated conditions without significant changes in physicochemical properties. In conclusion, the developed sustained release blend microspheres of cannabidiol showed promising results in terms of controlled drug release, enhanced stability, and improved drug encapsulation, making them a potential candidate for effective drug delivery.
Keywords: Cannabidiol, Sustained release, Microspheres, Solvent evaporation, HPMC, Ethyl cellulose, Guar gum, Drug entrapment, Buoyancy, Release kinetics.

Cite This Article:

Please cite this article in press Shivam Gaur et al., Formulation And Characterization Of Cannabidiol Sustained Release Blend Microspheres., Indo Am. J. P. Sci, 2026; 13(04).

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