Volume : 13, Issue : 04, April – 2026

Title:

ATOPIC DERMATITIS IN CHILDREN: SEVERITY, MANAGEMENT, AND QUALITY OF LIFE — A SYSTEMATIC REVIEW

Authors :

Atwar Hussain alali, Sami Abdullah almulhim

Abstract :

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder that predominantly affects children and poses a significant burden on patients, families, and healthcare systems. This systematic review aims to comprehensively evaluate disease severity, current management strategies, and the impact on quality of life (QoL) among pediatric populations. A structured literature search was conducted across PubMed, Embase, Cochrane Library, and Web of Science databases. Eligible studies included randomized controlled trials, observational studies, and systematic reviews focusing on children aged 0–18 years. Disease severity was assessed using validated tools such as SCORAD and EASI, while QoL was evaluated using CDLQI, IDQOL, and DFI indices.
A total of 13 studies met inclusion criteria. Findings demonstrate a strong correlation between increasing disease severity and worsening QoL, particularly affecting sleep, emotional well-being, and social functioning. Management approaches vary based on severity, ranging from topical therapies to systemic immunosuppressants and targeted biologics. Recent advancements, including dupilumab and Janus kinase (JAK) inhibitors, have shown significant efficacy in reducing disease severity and improving QoL outcomes. However, challenges remain in long-term disease control, adherence, and accessibility of advanced therapies.
In conclusion, pediatric AD requires a comprehensive, multidisciplinary management approach that addresses both clinical severity and psychosocial burden to improve overall outcomes.

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