Volume : 13, Issue : 04, April – 2026
Title:
MUCOADHESIVE AND GASTRORETENTIVE DRUG DELIVERY SYSTEMS IN CHRONOTHERAPEUTICS: RECENT ADVANCES IN CONTROLLED RELEASE, SITE-SPECIFIC DELIVERY, AND CIRCADIAN-BASED THERAPY
Authors :
Shubham G. Padol, Dr. Vishal R. Rasve*, Kavita A. Gaikwad, Sneha A. Mane, Sapna S. Ghuge, Dasrao Patil, Sunil S. Bhagat
Abstract :
Chronotherapeutics has emerged as a promising approach in modern drug delivery, emphasizing the synchronization of drug release with the body’s biological rhythms to enhance therapeutic efficacy and minimize adverse effects. Many physiological processes and disease conditions exhibit circadian variations, governed by the Circadian Rhythm, which significantly influence drug pharmacokinetics and pharmacodynamics. Conventional drug delivery systems often fail to address these temporal variations, leading to suboptimal therapeutic outcomes. In this context, advanced drug delivery strategies such as mucoadhesive and gastroretentive systems have gained considerable attention for their ability to prolong gastric residence time, enhance site-specific delivery, and improve bioavailability. The integration of these systems with chronotherapeutic principles enables precise control over both spatial and temporal drug release. Pulsatile drug delivery systems, time-controlled formulations, and stimuli-responsive systems play a crucial role in achieving chronomodulated release profiles that align with disease-specific circadian patterns. Recent advancements in this field include the development of smart polymers, nanotechnology-based gastroretentive systems, floating microspheres, and 3D-printed dosage forms, as well as the application of artificial intelligence for optimizing drug delivery schedules. These innovations have significantly improved the design and performance of chronotherapeutic systems, offering new opportunities for personalized medicine. This review provides a comprehensive overview of mucoadhesive and gastroretentive drug delivery systems in chronotherapeutics, highlighting recent advances in controlled release technologies, site-specific targeting, and circadian-based therapy. It also discusses current challenges, evaluation techniques, and future perspectives, emphasizing the potential of these systems to revolutionize the treatment of diseases with pronounced circadian patterns.
Keywords: Chronotherapeutics; Circadian rhythm; Mucoadhesive drug delivery; Gastroretentive systems; Pulsatile drug delivery; Controlled release; Site-specific delivery; Smart polymers; Nanotechnology; Chronomodulated release; Floating drug delivery systems; Personalized medicine.
Cite This Article:
Please cite this article in press Vishal R. Rasve et al., Mucoadhesive And Gastroretentive Drug Delivery Systems In Chronotherapeutics: Recent Advances In Controlled Release, Site-Specific Delivery, And Circadian-Based Therapy., Indo Am. J. P. Sci, 2026; 13(04).
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