Volume : 13, Issue : 04, April – 2026
Title:
DESIGN, DEVELOPMENT, AND IN VITRO EVALUATION OF CELECOXIB -LOADED TRANSFERSOMAL GEL
Authors :
Kishore Bandarapalle*, Chintha Sushmitha
Abstract :
The purpose of the present investigation was to design, development, and in vitro evaluation of celecoxib -loaded transfersomal gel Method: celecoxib -loaded transfersomal gel was prepared using Thin Film Hydration mechanism. Experiments using Fourier transform infrared spectroscopy and Differential Scanning Calorimetry were used to determine drug and excipients were compatible. 22 mathematical models have been employed for the optimization experiment in this work, which was carried out using Design Expert version 12 software. Vesicle size (Y1) and entrapment efficiency (Y2) are regarded as response variables or dependent factors, and the concentrations of lipids (in mg) and edge activators (in ml) are treated as independent factors. optimized formulation is having a high potential value i.e. – 32.1mV. High zeta potential value contributes to the stability of the formulation and the tendency to aggregate would be minimal. The Z average of the particle size for the improved formulation is discovered to be 249.2 nm and Transmission electron microscopy indicates the morphology of vesicles; the TEM pictures for CBT7 were found to be spherical with a uniform surface. The drug release percentage of CBT7 was 88.03 ±0.22 percent over 24 hours, following a regulated and predefined release pattern.
Cite This Article:
Please cite this article in press Kishore Bandarapalle et al., Design, Development, And In Vitro Evaluation Of Celecoxib -Loaded Transfersomal Gel., Indo Am. J. P. Sci, 2026; 13(04).
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