Volume : 13, Issue : 04, April – 2026
Title:
DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF LIPOSOMAL FORMULATIONS FOR IMPROVED BIOAVAILABILITY OF EPROSARTAN
Authors :
P. Prakash *, P Thanuja
Abstract :
The purpose of this study was to design, development, and characterization of liposomal formulations for improved bioavailability of Eprosartan. liposomal formulations, was prepared by dry film hydration method. Box-behnken design was introduced to optimize the formulation of polymeric nanoparticles Results: Fourier Transform Infra-Red (FTIR) studies indicate that the excipients added were compatible with the drug. Cumulative drug release in 7.4 pH phosphate buffer was found to be more than95.85%. formation of Liposomes from preliposomes having small Multilamellar vesicles and spherical in shape. Entrapment efficiency of optimized batch was found to be 75.80±0.35 %.Optimized batch having particle size 345.80nm±0.13 nm and polydispersity index of 0.281 which conclude that particles were in mono-disperse state. Scanning Electron microscopy confirmed that Liposomes are in spherical in shape. It concluded that most of the drug was entrapped in liposomes..
Key words: Bioavailability, solvent diffusion, Box-behnken design, Scanning electron microscopy & Particle size.
Cite This Article:
Please cite this article in press P. Prakash et al., Design, Development, And Characterization Of Liposomal Formulations For Improved Bioavailability Of Eprosartan., Indo Am. J. P. Sci, 2026; 13(04).
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