Volume : 13, Issue : 04, April – 2026
Title:
DEVELOPMENT AND CHARACTERIZATION OF POLYMERIC MICROSPHERES FOR CONTROLLED DELIVERY OF GLIMEPIRIDE
Authors :
Kishore Bandarapalle*, M Vaishnavi
Abstract :
The purpose of the present investigation was to formulate and evaluate microencapsulated glimepiride produced by the solvent evaporation method, Method: Microspheres were prepared using Carbopol 934 polymers by solvent evaporation method an characterized for their micromeritic properties and drug loading, as well as by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray Powder diffraction (XRPD) and scanning electron microscopy. In vitro release studies were performed in phosphate buffer (pH 7.4). Result: The resulting microspheres obtained by solvent evaporation method were white and free flowing in nature. The encapsulation efficiency was also found to be dependant on nature of polymer used in the formulation. The infrared spectra confirmed the stable character of glimepiride in the drug-loaded microspheres. Scanning electron microscopy revealed that the microspheres were spherical in nature. From the in vitro drug dissolution studies it was found that the sustaining effect of microspheres depended on the polymer concentration, amount of dispersant used and the type of polymer used in the formulation.
Key words: Microencapsulated, solvent evaporation method & by Fourier transform infrared spectroscopy.
Cite This Article:
Please cite this article in press Kishore Bandarapalle et al., Development And Characterization Of Polymeric Microspheres For Controlled Delivery Of Glimepiride., Indo Am. J. P. Sci, 2026; 13(04).
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