Volume : 13, Issue : 04, April – 2026
Title:
FORMULATION, OPTIMIZATION AND IN-VITRO CHARACTERIZATION OF ABACAVIR MUCOADHESIVE MICROSPHERES BY BOX BEHNKEN DESIGN
Authors :
Kishore Bandarapalle*, Pasupulati Mounika
Abstract :
The purpose of this study was to formulate and optimize mucoadhesive microspheres of Abacavir within Carbopol 934, Moringa oleifera, and Tamarindus indica as a carrier polymer and mucoadhesive polymer for controlling the release of Abacavir. The ionic gelation technique was used for preparation of microspheres of Abacavir and the Box-Behnken design was employed. Results: Fourier transform infrared spectroscopy studies indicate that no interaction or minor at molecular level suggest the polymers added were compatible with the drug. The EE of ABC and were found to be in the range of 86.14 ± 0.88 to 91.83 ± 0.99 for A1 toA 3. and the average particle size 805.73±10.16 to 896.73±10.16 μm for A1 to A3: The analysis of variance showed a significant effect of independent variables. The scaning electron microscopy (SEM) analysis showed that the microspheres were spherical and free-flowing. The microspheres of Abacavir were stable after thee month stability study at accelerated condition..
Key words: Carbopol 934, ionic gelation technique, Box-Behnken design & Fourier transform infrared spectroscopy.
Cite This Article:
Please cite this article in press Kishore Bandarapalle et al., Formulation, Optimization And In-Vitro Characterization Of Abacavir Mucoadhesive Microspheres By Box Behnken Design., Indo Am. J. P. Sci, 2026; 13(04).
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