Volume : 13, Issue : 04, April – 2026

Title:

FORMULATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE TABLETS OF SIMVASTATIN

Authors :

Annpurna Shukla, Manoj R. Chincholikar, Dr. Jagdish Chandra Rathi

Abstract :

The present study focused on the development and optimization of gastroretentive mucoadhesive tablets of Simvastatin using direct compression technique. Preformulation studies confirmed its physicochemical properties, solubility profile, and purity, with λmax observed at 231 nm in 0.1 N HCl and excellent linearity (R² = 0.995). FT-IR analysis revealed no drug–excipient interactions, ensuring compatibility. Powder blends demonstrated acceptable flow and compressibility (angle of repose 26–31°, compressibility index 25–35%, Hausner’s ratio 1.33–1.55), supporting ease of processing. Post-compression evaluation showed uniform weight, thickness, diameter, hardness (5.0–5.5 kg/cm²), friability (<1%), and drug content (98–99%), confirming mechanical strength and dosage uniformity. The tablets exhibited excellent swelling behavior (97–121% hydration after 12 hr), rapid buoyancy initiation (lag time 25–33 sec), and prolonged gastric retention (20–23 hr). Strong mucoadhesion (3.4–3.8 N) further supported gastric residence. In-vitro release studies demonstrated sustained drug release, with dissolution data fitting both Higuchi and Korsmeyer–Peppas models (R² = 0.993). The release exponent (n = 0.558) indicated anomalous transport, involving both diffusion and polymer relaxation. Overall, the optimized formulation (GM-4) achieved prolonged gastric retention, controlled release, and enhanced bioavailability of Simvastatin. This once-daily dosage form offers improved patient compliance, reduced dosing frequency, and better therapeutic outcomes in the management of hypercholesterolemia and cardiovascular disease risk. The study highlights gastroretentive mucoadhesive tablets as a promising approach for sustained oral delivery of Simvastatin
KEYWORDS: Gastroretentive, Mucoadhesive, Ttablet, Simvastatin, Compression

Cite This Article:

Please cite this article in press Annpurna Shukla et al., Formulation And Evaluation Of Gastroretentive Mucoadhesive Tablets Of Simvastatin., Indo Am. J. P. Sci, 2026; 13(04).

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