Volume : 13, Issue : 04, April – 2026
Title:
A COMPREHENSIVE REVIEW OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: MECHANISM, USES AND SAFETY
Authors :
T Rajitha Sree*, P Jessica, Nasu Priyadarshini, Najam Uddin Siddiqui, Chandra Sekhara Rao Baru
Abstract :
One of the most Popular treatments for treating pain, inflammation and fever is non-steroidal anti-inflammatory drugs (NSAIDS). Cyclooxydenase (COX) enzyme inhibition, which results in decreased prostaglandin synthesis involved in Inflammatory pathways is the main mechanism by which their therapeutic benefits are mediated. The mechanism of action categorization pharmacokinetic characteristics, and clinical uses of NSAIDs are all covered in detail in this article. It emphasises how COX- 1 and Cox- 2 selectively effects safety and efficacy profiles. Pharmacokinetic elements that affect drug distribution in inflammatory tissues are highlighted including absorption common distribution metabolism and elimination. The article also describes their involvement in anti-piracies and anti-thrombotic therapy as well as common therapeutic use in musculoskeletal inflammatory and post-operative disorders. Despite its therapeutic advantages NSAIDs must be used carefully because of side effects such gastrointestinal discomfort common renal impairment and medication interactions. The goal of recent developments is to increase safety and efficacy by concentrating or innovative hybrid molecules and selective COX2 inhibitors. NSAIDs are still necessary in clinical practice overall but their usage necessities careful assessment of each patients unique characteristics and risk profile.
Keywords: Metformin, Lactic Acidosis, Type 2 Diabetes Mellitus, Renal Failure, Adverse Drug Reaction
Cite This Article:
Please cite this article in press T Rajitha Sree et al., A Comprehensive Review of Nonsteroidal Anti-Inflammatory Drugs: Mechanism, Uses and Safety, Indo Am. J. P. Sci, 2026; 13(04).
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