Volume : 13, Issue : 08, August – 2026
Title:
EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF TINOSPORA CORDIFOLIA IN GENTAMICIN AND CISPLATIN INDUCED NEPHROTOXICITY IN RATS
Authors :
Akash Kumar Singh*, Dr.Sai Kiran, Dr.N. Raghunandhan
Abstract :
Cisplatin induced nephrotoxicity is a major contributor to Acute Kidney Injury (AKI) resulting from free radicals induced oxidative stress. Tinospora cordifolia is an Indian medicinal plant, widely used because of its antioxidant activity. Due to limited scientific literature exploring its nephroprotective potential, the present study was designed to investigate the nephroprotective effect of aqueous extract of Tinospora cordifolia against Cisplatin induced nephrotoxicity in albino rats.
The study was commenced following approval from Institutional Animal Ethical Committee. Twenty-four rats were randomized into four groups of six animals each. Total duration of study was 21 days. Group I received normal saline p.o., group II received normal saline along with Cisplatin on last 5 days, group III and IV received Tinospora cordifolia in graded doses p.o. along with Cisplatin on last 5 days. Injection Cisplatin (10mg/kg) i.p. was given once daily for last 5 days to induce nephrotoxicity in rats of groups II, III and IV. The rats were sacrificed under anaesthesia, blood samples analyzed for blood urea nitrogen (BUN) and serum creatinine levels and histopathological changes were studied. Statistical analysis was done using ANOVA followed by post hoc test. Tinospora cordifolia pre-treated groups exhibited significant (p<0.001) limitation in rise in levels of BUN and serum creatinine in a dose dependent manner. Histopathological observations further corroborated the biochemical findings. The present study concluded that aqueous extract of Tinospora cordifolia possesses nephroprotective potential against gentamicin induced nephrotoxicity
Keywords: Cisplatin, Tinospora cordifolia, Nephrotoxicity and Nephroprotective activity.
Cite This Article:
Please cite this article in press Akash Kumar Singh et al., Evaluation of Nephroprotective activity of Ethanolic extract of Tinospora Cordifolia in Gentamicin and Cisplatin induced Nephrotoxicity in Rats,, Indo Am. J. P. Sci, 2026; 13(08).
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