Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF SWERTIA CHIRAYITA IN WISTAR RATS

Authors :

Mekala Akhila*, Dr.Sai Kiran, Dr.n. Raghunandhan

Abstract :

In this study we investigated the in vivo Hepatoprotective activity of aqueous extract of Swertia chirayita in induced hepatotoxicity using Wistar rats of either sex as model. Hepatotoxicity was induced by the administration of 3% CMC per 100g body weight). Swertia chirayita extract at different dose levels (200 and 400mg/kg, p.o.) showed the dose dependent hepatoprotective effect and was compared with well-known standard hepatoprotective Silymarain (100mg/kg).
The rats were divided into five groups with three rats in each for three models. Group I (Control) served as normal and received the vehicle alone (Sterile distilled water, 10 ml/kg, p.o.) for 21 days. Group II (control and 40% ethanol) animals on the 21 days. Group III Received 40% ethanol v/v (2.0ml/l00g body wt, p.o.) for 21 days and standard drug silymarin (25 mg/kg. p.o.) for 21 days once daily and IV were treated with 40% ethanol and aqueous extract Swertia chirayita (400 mg/kg) 21 days once daily. Group V was treated with Received 40% ethanol and aqueous extract of Swertia chirayita (200 mg/kg) 21 days once daily the animals were sacrificed 48 h after the last injection of hepatotoxic drugs under mild ether anesthesia. The blood was collected and allowed to stand for 30 min at 37°C and then centrifuged to separate the serum to estimate various biochemical parameters.
In hepatoprotective studies, the toxicity elevated levels of serum marker enzymes Total Bilirubin ALT, AST, ALP, SGOP and SGPT levels. Ethanol induced hepatotoxicity was significantly prevented by pretreatment ethanolic extract of leaves. Decrease in wet liver weight, reduction in elevated biochemical parameter levels like serum SGPT, SGOT, and total bilirubin, after treatment with aqueous extract of Swertia chirayita confirmed the hepatoprotective effect of extract under study. In liver injury models in rats’ restoration of hepatic cells with minor fatty changes and absence of necrosis after treatment with extract was observed, indicating satisfactory hepatoprotection.
The data obtained from animal experiments are expressed as mean ± SEM (standard error of mean). For statistical analysis data were subjected to analysis of variance (ANOVA) followed by Student’s t-test. Values are considered statistically significant at p < 0.01 for ANOVA and P < 0.05 for t-test.
Keywords: Swertia chirayita, Hepatoprotective activity, Alkaline Phosphate, Aspartate amino trasferase, Alanine amino transferase.

Cite This Article:

Please cite this article in press Mekala Akhila et al., Evaluation of Hepatoprotective activity of aqueous extract of Swertia Chirayita in Wistar rats. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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