Volume : 13, Issue : 08, August – 2026

Title:

FORMULATION DEVELOPMENT AND EVALUATION OF DORZOLAMIDE HYDROCHLORIDE NANOPARTICLES

Authors :

G. Soujanya*, Dr. G. Anil Kumar

Abstract :

The objective of this present work was to develop Nanoparticle of Dorzolamide hydrochloride. The proposed Dorzolamide hydrochloride polymer loaded with nanoparticles was prepared by emulsification sonication method. Nanoparticles represent a promising drug delivery system of sustained and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate polymer loaded nanoparticles containing Dorzolamide hydrochloride in different drug to polymer ratio. SEM indicated that nanoparticles have a discrete spherical structure. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The in vitro release behavior from all the drug loaded batches was found to be Peppas release and provided sustained release over a period of 48 h. The developed formulation overcome and alleviates the drawbacks and limitations of Dorzolamide hydrochloride sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Dorzolamide hydrochloride.
Keywords: Dorzolamide hydrochloride, Nanoparticles.

Cite This Article:

Please cite this article in press G. Soujanya et al., Formulation development and evaluation of Dorzolamide Hydrochloride Nanoparticles. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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