Volume : 13, Issue : 08, August – 2026

Title:

FORMULATE AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF PREGABALIN

Authors :

Pindi Sruthi *, Mr. M.sunil

Abstract :

Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system.
Pregabalin 150 mg pulsatile release tablets were prepared by direct compression method and evaluated for thickness, hardness, weight variation, friability, drug content and in vitro release of drug. In vitro drug release was carried out using USP type II apparatus at 50 rpm in 900 ml of dissolution media for 8 hrs. Mean dissolution time is used to evaluate drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Various kinetics models were applied to the dissolution profile to determine the drug release kinetics. All the physical characteristics evaluated for the tablets were obtained to be within the acceptable limits. Finally it was clear that core polymer Sodium Starch Glycolate and coating polymer Xanthan Gum is good candidate for preparing pulsatile tablets of Pregabalin.
Keywords: Pregabalin , Dammar gum, Guar Gum, Xanthan Gum

Cite This Article:

Please cite this article in press Pindi Sruthi et al., Formulate and evaluation of pulsatile drug delivery system of Pregabalin. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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