Volume : 13, Issue : 08, August – 2026

Title:

THERAPEUTIC TARGETING WITH PASSIFLORA FOETIDA LINN. PHYTOCHEMICALS: MECHANISMS OF ACTION AND CLINICAL PERSPECTIVES

Authors :

Deepak Jain*, Omkar Rai, Soma Sekhar Pulamarasetti, Vishva Prakash

Abstract :

Passiflora foetida Linn. (Passifloraceae), popularly known as stinking passionflower or wild maracuja, is a pantropical climbing vine long employed in folk medicine for anxiety, insomnia, respiratory and gastrointestinal ailments, wounds, and inflammatory disorders. Contemporary pharmacognostic investigation has confirmed that the leaves, flowers, fruit pulp, seeds and roots of P. foetida are rich in C-glycosyl flavonoids (vitexin, isovitexin, orientin, isoorientin), aglycone flavonoids (quercetin, kaempferol, luteolin, chrysoeriol, apigenin, chrysin, rutin), phenolic acids, coumarins, saponins, alkaloids, cyanogenic (cyclopentanoid) glycosides and volatile terpenoids. These constituents underlie a broad, multi-target pharmacological profile encompassing anxiolytic-sedative, anti-inflammatory, antioxidant, antimicrobial, antidiabetic, hepatoprotective, antiulcer and anticancer/pro-apoptotic activities, mediated through modulation of GABAergic neurotransmission, suppression of the NF-κB/MAPK inflammatory cascade and cyclo-oxygenase-2 (COX-2), scavenging of reactive oxygen species, inhibition of carbohydrate-hydrolysing enzymes (α-amylase and α-glucosidase), disruption of microbial membranes, and induction of mitochondria-dependent apoptosis in tumour cell lines. This review synthesises the current pharmacognostical, phytochemical, pharmacological and toxicological literature on P. foetida, correlates its major bioactive constituents with their proposed molecular mechanisms of action, and critically appraises the translational gap between the extensive preclinical evidence base and the near-total absence of controlled human clinical trials specific to this species. Standardisation of extracts, quantification of the cyanogenic-glycoside burden for safety assurance, and well-designed randomised clinical studies are identified as priority requirements before P. foetida-derived phytopharmaceuticals or nutraceuticals can be rationally advanced toward clinical use.
Keywords: Passiflora foetida; phytochemicals; C-glycosyl flavonoids; mechanism of action; anxiolytic; anti-inflammatory; anticancer; clinical translation

Cite This Article:

Please cite this article in press Deepak Jain et al Therapeutic Targeting with Passiflora foetida Linn. Phytochemicals: Mechanisms of Action and Clinical Perspectives. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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