Volume : 13, Issue : 08, August – 2026

Title:

CASE REPORT: ATORVASTATIN – INDUCED PERIPHERAL NEUROPATHY IN AN ELDERLY PATIENT WITH CORONARY ARTERY DISEASE

Authors :

Neeraja Sunil, Dr. Harikrishnan S, Dr. Akhil Joseph Issac, Dr. Manish Mohan M

Abstract :

An 81- year- old man with coronary artery disease, hypertension, and benign prostatic hyperplasia developed bilateral lower limb pain suggestive of peripheral neuropathy during long-term atorvastatin therapy. Cardiac evaluation was unremarkable, and glycemic parameters remained within the normal range, making diabetic neuropathy less likely. This case emphasizes the importance of early recognition of statin-associated neurological adverse effects, particularly in elderly patients receiving long-term therapy.
Keywords: Atorvastatin, Statin-induced neuropathy, Peripheral neuropathy, adverse drug reaction, and coronary artery disease.

Cite This Article:

Please cite this article in press Neeraja Sunil et al., Case Report: Atorvastatin – Induced Peripheral Neuropathy In An Elderly Patient With Coronary Artery Disease. Indo Am. J. P. Sci, 2026; 13(08).

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Volume : 13, Issue : 08, August – 2026

Title:

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF SAPINDUS EMARGINATUS IN RATS

Authors :

Chinthala Jamima*, Dr.R.narasimha Rao, Dr.N. Raghunandhan

Abstract :

Obesity and hyperlipidemia have become major disorders predominantly causing prevailing cardiovascular diseases and ultimately death. The prolonged use of anti-obesity drugs and statins for reducing obesity and blood lipid levels is leading toward adverse effects of kidneys and muscles, specifically rhabdomyolysis. The objective of this study is to evaluate potential of seeds of Sapindus emarginatus against hyperlipidemia. In this model of Hyperlipidemia, 30 adult male wistar rats (200-250gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 100 and 200 mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. The outcomes of this study were expressed as mean standard error and data were evaluated by using analysis of variance followed by multiple comparisons. Oral administration of 100 mg/ kg and 200mg/kg body weight of Methanolic extract residual fraction of Moringa oleifera. Leaves exhibited a significant reduction (P < 0.01) in serum lipid parameters such as triglycerides, total cholesterol, low density lipoprotein (LDL), very LDL and increase in high density lipoprotein in hyperlipidemic rats when compared with hyperlipidemic control in both models. Our results demonstrated that Methanolic extract fraction of Sesbania grandiflora. Possessed significant antihyperlipidemic activity.
Keywords: Sesbania grandiflora, Cholesterol, LDL, triglycerides and antihyperlipidemic activity.

Cite This Article:

Please cite this article in press Chinthala Jamimaet al., Evaluation of Antihyperlipidemic activity of Sapindus Emarginatus in rats,, Indo Am. J. P. Sci, 2026; 13(08).

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