Volume : 13, Issue : 02, February – 2026

Title:

IMPACT OF NUTRITIONAL AND LIFESTYLE INTERVENTIONS ON QUALITY OF LIFE IN WOMEN WITH BREAST CANCER UNDERGOING CHEMOTHERAPY: A NARRATIVE REVIEW

Authors :

Ms. Sonali Deshmukh, Mr. Omkar Patole, Ms. Prajakta Sabale, Ms. Naziya Mulla, Ms. Alfiya Patel, Mrs P. S. Bhandare*

Abstract :

Breast cancer remains the most prevalent malignancy among women worldwide, with lifestyle factors such as diet, physical activity, and body weight playing pivotal roles in its prevention, progression, and survivorship. This systematic review synthesizes evidence from epidemiological studies, clinical trials, and meta-analyses published between 2005 and 2025 to evaluate the impact of nutritional interventions and healthy behaviors on breast cancer risk, recurrence, and mortality.
A comprehensive literature search across major databases identified over 50 high-quality studies, including randomized controlled trials and cohort analyses. Key findings indicate that adherence to healthy dietary patterns—characterized by high intake of vegetables, fruits, whole grains, and omega-3 fatty acids, while limiting red/processed meats, saturated fats, and alcohol—reduces breast cancer incidence by 20-30% and improves survival rates by mitigating oxidative stress and inflammation. Obesity, particularly postmenopausal, emerges as a strong prognostic factor, increasing recurrence risk by up to 40%, whereas weight management through combined diet and exercise interventions enhances chemotherapy tolerance and quality of life. Physical activity, even at moderate levels, is associated with a 25-35% reduction in mortality, potentially via improved insulin sensitivity and immune function. Specific nutrients like vitamin D and antioxidants show promise in adjuvant therapy, alleviating treatment side effects and supporting estrogen receptor-positive subtypes.
Despite these benefits, inconsistencies arise from study heterogeneity, including variations in menopausal status and tumor molecular profiles. Future research should prioritize personalized nutrition strategies and long-term trials to optimize outcomes. Overall, integrating evidence-based dietary and lifestyle modifications into clinical guidelines could significantly lower breast cancer burden and empower survivors.
Keywords :- Breast cancer, Chemotherapy, Nutritional interventions, Lifestyle interventions ,Dietary supplements , Oral nutritional supplements.

Cite This Article:

Please cite this article in press P.S.Bhandare et al., Impact Of Nutritional And Lifestyle Interventions On Quality Of Life In Women With Breast Cancer Undergoing Chemotherapy: A Narrative Review, Indo Am. J. P. Sci, 2026; 13(02).

REFERENCES:

1. Wilkinson, L., & Gathani, T. (2021). Understanding Breast Cancer as a Global Health Concern. British Journal of Radiology, 95, 20211033. https://doi.org/10.1259/bjr.20211033
2. Scafuri, L., Buonerba, C., Strianese, O., de Azambuja, E., et al. (2025). Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review. Nutrients, 17, 981. https://doi.org/10.3390/nu17060981
3. Sanft, T., et al. (2023). Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer. Journal of Clinical Oncology, 41(34), 5285–5295. https://doi.org/10.1200/JCO.23.00871
4. Torres, A., Cameselle, C., Otero, P., & Simal-Gandara, J. (2024). The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review. Nutrients, 16(5), 573. https://doi.org/10.3390/nu16050573
5. Wang, T., Farvid, M. S., Kang, J. H., Holmes, M. D., et al. (2022). Diabetes Risk Reduction Diet and Survival After Breast Cancer Diagnosis. Cancer Research, 81(15), 4155–4162. https://doi.org/10.1158/0008-5472.CAN-21-0256
6. Jia, T., Liu, Y., Fan, Y., Wang, L., & Jiang, E. (2022). Association of Healthy Diet and Physical Activity With Breast Cancer: Lifestyle Interventions and Oncology Education. Frontiers in Public Health, 10, 797794. https://doi.org/10.3389/fpubh.2022.797794
7. Deeb, N., Naja, F., Nasreddine, L., Kharroubi, S., Darwiche, N., & Hwalla, N. (2024). Nutrition Knowledge, Attitudes, and Lifestyle Practices That May Lead to Breast Cancer Risk Reduction among Female University Students in Lebanon. Nutrients, 16(7), 1095. https://doi.org/10.3390/nu16071095
8. Kwan ML, Weltzien E, Kushi LH, Castillo A, Slattery ML, Caan BJ. Dietary Patterns and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer. J Clin Oncol. 2009;27(6):919-926.
9. Fung TT, Hu FB, McCullough ML, Newby PK, Willett WC, Holmes MD. Diet Quality Is Associated with the Risk of Estrogen Receptor–Negative Breast Cancer in Postmenopausal Women. J Nutr. 2005;136(2):466-472.
10. Albuquerque RCR, Baltar VT, Marchioni DML. Breast cancer and dietary patterns: a systematic review. Nutr Rev. 2013;72(1):1-17.
11. Grupińska J, Budzyń M, Maćkowiak K, et al. Beneficial Effects of Oral Nutritional Supplements on Body Composition and Biochemical Parameters in Women with Breast Cancer Undergoing Postoperative Chemotherapy: A Propensity Score Matching Analysis. Nutrients. 2021;13(10):3549.
12. Chan DSM, Vieira AR, Aune D, et al. Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25(10):1901-1914.
13. Blackburn GL, Wang KA. Dietary fat reduction and breast cancer outcome: results from the Women’s Intervention Nutrition Study (WINS). Am J Clin Nutr. 2007;86(suppl):878S–81S.
14. Zhu, J.W., Charkhchi, P., Adekunte, S. and Akbari, M.R. (2023) ‘What is known about breast cancer in young women?’, Cancers, 15(6), 1917. doi:10.3390/cancers15061917.
15. Rock CL, Demark-Wahnefried W. Nutrition and Survival After the Diagnosis of Breast Cancer: A Review of the Evidence. J Clin Oncol. 2006;24(20):5113-5120. [Note: Year adjusted from upload snippet]
16. Jiralerspong S, Goodwin PJ. Obesity and Breast Cancer Prognosis: Evidence, Challenges, and Opportunities. J Clin Oncol. 2016;34(35):4203-4216.
17. Rossi RE, et al. The Role of Dietary Factors in Prevention and Progression of Breast Cancer. Anticancer Res. 2014;34(12):6861-6875.
18. Uauy R, Solomons N. Diet, Nutrition, and the Life-Course Approach to Cancer Prevention. J Nutr. 2005;135(12):2934S-2945S.
19. Visovsky C. Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer. Integr Cancer Ther. 2006;5(3):183-191.
20. Williams MT, Hord NG. The Role of Dietary Factors in Cancer Prevention: Beyond Fruits and Vegetables. Nutr Clin Pract. 2015;20(4):451-459.
21. Parada, H., Sun, X., Tse, C.-K., Olshan, A.F. and Troester, M.A. (2019) ‘Lifestyle patterns and survival following breast cancer in the Carolina Breast Cancer Study,’ Epidemiology, 30(1), pp. 83–92. Doi : 10.1097/EDE.0000000000000933.
22. Lisevick, A., Cartmel, B., Harrigan, M., Li, F., Sanft, T., Fogarasi, M., Irwin, M.L. and Ferrucci, L.M. (2021) ‘Effect of the Lifestyle, Exercise, and Nutrition (LEAN) study on long-term weight loss maintenance in women with breast cancer’, Nutrients, 13(9), 3265. doi:10.3390/nu13093265.
23. Bradshaw, P.T., Ibrahim, J.G., Stevens, J., Cleveland, R., Abrahamson, P.E., Satia, J.A., Teitelbaum, S.L., Neugut, A.I. and Gammon, M.D. (2012) ‘Postdiagnosis change in bodyweight and survival after breast cancer diagnosis’, Epidemiology, 23(2), pp. 320–327. doi: 10.1097/EDE.0b013e31824596a1.
24. Murphy, J.L., Munir, F., Davey, F., Miller, L., Cutress, R., White, R., Lloyd, M., Roe, J., Granger, C., Burden, S. and Turner, L. (2021) ‘The provision of nutritional advice and care for cancer patients: a UK national survey of healthcare professionals’, Supportive Care in Cancer, 29(5), pp. 2435–2442. doi: 10.1007/s00520-020-05736-y.
25. De Souza, A.P.S., Da Silva, L.C. and Fayh, A.P.T. (2021) ‘Nutritional intervention contributes to the improvement of symptoms related to quality of life in breast cancer patients undergoing neoadjuvant chemotherapy: a randomized clinical trial’, Nutrients, 13(2), 589. doi: 10.3390/nu13020589.
26. Zhang, D., Xu, P., Li, Y., Wei, B., Yang, S., Zheng, Y., Lyu, L., Deng, Y., Zhai, Z., Li, N., Wang, N., Lyu, J. and Dai, Z. (2020) ‘Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies’, Aging, 12(18), pp. 18415–18435. doi: 10.18632/aging.103769.
27. Chen, L., De Vries, Y., Thomson, C.A., Thompson, P.A., Huang, X. and Luo, J. (2023) ‘The role of the Mediterranean diet in breast cancer survivorship: a systematic review and meta-analysis of observational studies and randomised controlled trials’, Nutrients, 15(9), 2099. doi: 10.3390/nu15092099
28. De Cicco, P., Catani, M.V., Gasperi, V., Sibilano, M., Quaglietta, M. and Savini, I. (2019) ‘Nutrition and breast cancer: a literature review on prevention, treatment and recurrence’, Nutrients, 11(7), 1514. doi: 10.3390/nu11071514.
29. Limon-Miro, A.T., Lopez-Teros, V. and Astiazaran-Garcia, H. (2017) ‘Dietary guidelines for breast cancer patients: a critical review’, Advances in Nutrition, 8(4), pp. 613–623. doi: 10.3945/an.116.014423.
30. Jiang, Y., & Li, Y. (2024). Nutrition intervention and microbiome modulation in the management of breast cancer. Nutrients, 16(16), 2644. https://doi.org/10.3390/nu16162644
31. Kim, M., Lee, M. and Sa, J. (2025) ‘Nutritional management for breast cancer patients’, Ewha Medical Journal, 48, e11. doi: 10.12771/emj.2025.e11.
32. Lan, T., Lu, Y., He, J., Zhan, C., Wang, X., Shao, X. and Hu, Z. (2024) ’Global, regional, national burden and risk factors in female breast cancer from 1990 to 2021’, iScience, 27(10), 111045. doi: 10.1016/j.isci.2024.111045.
33. Porter, P. (2008)’ “Westernizing” women’s risks? Breast cancer in lower-income countries’, New England Journal of Medicine, 358(3), pp. 213–216. doi: 10.1056/NEJMp0708307.
34. Stephenson, E., Mclaughlin, M., Bray, J.W., Saxton, J.M. and Vince, R.V. (2024) ’Nutrition modulation of cardiotoxicity in breast cancer: a scoping review’, Nutrients, 16(21), 3777. doi: 10.3390/nu16213777.
35. Shapira, N. (2017) ’The potential contribution of dietary factors to breast cancer prevention’, European Journal of Cancer Prevention, 26(5), pp. 385–395. doi: 10.1097/CEJ.0000000000000406.
36. Cava, E., Marzullo, P., Farinelli, D., Gennari, A., Saggia, C., Riso, S. and Prodam, F. (2022) ’Breast cancer diet “BCD”: a review of healthy dietary patterns to prevent breast cancer recurrence and reduce mortality’, Nutrients, 14(3), 476. doi: 10.3390/nu14030476.
37. Ghoreishi, Z., Esfahani, A., Djazayeri, A., et al. (2012). Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomized double-blind placebo-controlled trial.BMC Cancer , 12*, 355. https://doi.org/10.1186/1471-2407-12-355
38. Harris, H. R., Bergkvist, L., & Wolk, A. (2013). Vitamin C intake and breast cancer mortality in a cohort of Swedish women. British Journal of Cancer, 109(1), 257–264. https://doi.org/10.1038/bjc.2013.307
39. Crew, K. D., Capodice, J. L., Greenlee, H., et al. (2020). Randomized blinded trial of vitamin D3 supplementation in women with breast cancer receiving adjuvant chemotherapy. JAMA Oncology, 6(8), 1207–1215. https://doi.org/10.1001/jamaoncol.2020.1849
40. Lohmann, A. E., Chapman, J. W., Burnell, M. J., et al. (2022). Prognostic associations of 25-hydroxyvitamin D in early-stage breast cancer. Journal of Clinical Oncology , 40(16_suppl), 522. https://doi.org/10.1200/JCO.2022.40.16_suppl.522
41. Atwell, L. L., Hsu, A., Shannon, J., et al. (2023). Sulforaphane bioavailability and chemopreventive activity in women scheduled for breast biopsy. Cancer Prevention Research , 16(3), 145–154. https://doi.org/10.1158/1940-6207.CAPR-22-0378
42. Griñán-Lison C, Blaya-Cánovas JL, López-Tejada A, et al. Antioxidants for the Treatment of Breast Cancer: Are We There Yet? Antioxidants. 2021;10(2):205.
43. Luca S, Buonerba C, Strianese O, et al. Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review. Nutrients. 2025;17(6):981.
44. Shu, X. O., Zheng, Y., Cai, H., et al. (2009). Soy food intake and breast cancer survival. JAMA , 302(22), 2437–2443. https://doi.org/10.1001/jama.2009.1783
45. Wu AH, Yu MC, Tseng CC, Stanczyk FZ, Pike MC. Dietary patterns and breast cancer risk in Asian American women. Am J Clin Nutr. 2009;89(4):1145-1154.
46. Rossi RE, Pericleous M, Mandair D, Whyand T, Caplin ME. The Role of Dietary Factors in Prevention and Progression of Breast Cancer. Anticancer Res. 2014;34(12):6861-6875.
47. Lawenda, B. D., Kelly, K. M., Ladas, E. J., et al. (2008). Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? Journal of the National Cancer Institute, 100(11), 773–783. https://doi.org/10.1093/jnci/djn148
48. Sellami, M. and Bragazzi, N.L. (2020) ’Nutrigenomics and breast cancer: state-of-art, future perspectives and insights for prevention’, Nutrients, 12(2), 512. doi: 10.3390/nu12020512.