Volume : 13, Issue : 01, January – 2026

Title:

ASSESSMENT OF CICER ARIETINUM’S ANTIPYRETIC AND ANALGESIC PROPERTIES IN MALE SPRAGUE DAWLEY RATS

Authors :

Gunti Pavani, Meena Kumari*, Dr I Veena Rani

Abstract :

This study evaluated the analgesic activity of a plant extract using the formalin-induced paw licking model in mice. Six groups were used: a normal control receiving 2.5% formalin, a negative control treated with 3% DMSO, a positive control given diclofenac (15 mg/kg), and three test groups administered the plant extract at doses of 150, 200, and 250 mg/kg body weight, respectively, prior to formalin injection. Results showed that the plant extract produced a significant, dose-dependent reduction in paw licking time compared to the negative control, with the highest dose exhibiting analgesic effects comparable to diclofenac (p < 0.01). These findings suggest that the plant extract possesses potent analgesic properties, potentially mediated through anti-inflammatory mechanisms. Further studies are warranted to isolate active constituents and elucidate the mechanism of action. The extract shows promise as a natural alternative for pain management.
Keywords: pain, formalin-induced, analgesic activity, anti-inflammatory

Cite This Article:

Please cite this article in press Meena Kumari et al., Assessment Of Cicer Arietinum’s Antipyretic And Analgesic Properties In Male Sprague Dawley Rats, Indo Am. J. P. Sci, 2026; 13(01).

REFERENCES:

1. Sweetman, S. C. Martindale: The Complete Drug Reference. Pharmaceutical Press: London, 2009;2.
2. Apkarian, A. V. In: Raj’s Practical Management of Pain; Benzon, H., Rathmell, J. P., Wu, C. L., Turk, D. C., Argoff, C. E., Eds.; Elsevier: Philadelphia, 2008; pp 151–173.
3. Sifton, D. W. Physicians’ Desk Reference for Herbal Medicines. Medical Economics Company: Montvale, NJ, 2001.
4. Nthiga, P. M., Kamau, J. K., Safari, V. Z., Mwonjoria, J. K., Mburu, D. N. and Ngugi, M. P. (2016). Antipyretic Potential of Methanolic Stem Bark Extracts of Harrisonia Abyssinica Oliv and Landolphia Buchananii (Hallier F.) Stapf in Wistar Rats. Journal of Applied Pharmacology, 8(3),1-7.
5. Wan, J., Gong, X., Jiang, R., Zhang, Z. and Zhang, L. (2013). Antipyretic and anti‐inflammatory effects of asiaticoside in lipopolysaccharide‐treated rat through up‐regulation of heme oxygenase‐1. Phytotherapy Research, 27(8), 1136-1142.
6. Hukkeri, V.I., Nagathan, C.V. and Karadi, R.V. (2006). Antipyretic and wound healing activities of Moringa oeifera in rats. Indian Journal of Pharmaceutical Sciences, 68: 124-32.
7. Yemitan, O. K. and Adeyemi, O. O. (2017). Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models. Pharmaceutical biology, 55(1), 898-905.
8. Hunskaar, S. and Hole, K. (1987). The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain, 30(1), 103-114.
9. Tjolsen, A., Berge, O. G., Hunskaar, S., Rosland, J. H., Hole, K. (1992). The formalin test: an evaluation of the method. Pain. 51(1), 5–17.