Volume : 13, Issue : 01, January – 2026

Title:

ASSESSING THE HEPATOPROTECTIVE POTENTIAL OF MUCUNA PRURIENS METHANOLIC EXTRACT IN MALE SPRAGUE DAWLEY RATS

Authors :

Mekala Priyanka, Madhurima Yadav*, Dr I Veena Rani

Abstract :

This study investigates the hepatoprotective and antioxidant effects of Mucuna pruriens methanolic extract (MPME) against paracetamol-induced liver toxicity in rats. Paracetamol (3 g/kg) was administered orally for 14 days to induce hepatotoxicity, followed by treatment with either Silymarin (100 mg/kg) or MPME at two doses (250 mg/kg and 500 mg/kg). Biochemical parameters including AST, ALT, ALP, bilirubin, LDH, and total protein were measured, along with antioxidant markers such as GSH, SOD, CAT, and MDA. Paracetamol significantly increased liver enzymes and MDA levels, while reducing antioxidant enzyme levels and total protein, indicating oxidative stress and liver damage. Co-administration of MPME significantly reversed these changes in a dose-dependent manner, with the 500 mg/kg dose showing effects comparable to Silymarin. The observed hepatoprotective activity is likely due to the presence of flavonoids, phenols, and other phytochemicals in the extract. These results suggest that MPME has strong potential as a natural hepatoprotective agent and support its traditional use in liver disorders.
Keywords: hepatoprotective, antioxidant, MPME, Mucuna pruriens, AST, ALT, ALP

Cite This Article:

Please cite this article in press Madhurima Yadav et al., Assessing The Hepatoprotective Potential Of Mucuna Pruriens Methanolic Extract In Male Sprague Dawley Rats, Indo Am. J. P. Sci, 2026; 13(01).

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