Volume : 13, Issue : 01, January – 2026
Title:
DESIGN, PREPARE AND OPTIMIZATION OF PLGA NANOPARTICLES LOADED PACLITAXEL
Authors :
Dr. Nansri Saha*, K.Rathna Kumari, Dr A Saritha
Abstract :
Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance the therapeutic efficacy and bioavailability of poorly water-soluble chemotherapeutic agents. In this study, paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were designed, prepared, and optimized using the nanoprecipitation method. Various formulation parameters, including polymer concentration, drug-to-polymer ratio, and stabilizer concentration, were systematically investigated to achieve nanoparticles with desired particle size, surface charge, drug entrapment efficiency, and controlled release profile. The prepared nanoparticles were characterized by particle size analysis, zeta potential measurement, and scanning electron microscopy (SEM), which revealed spherical and uniform particles with an average size of approximately 200 nm and good colloidal stability. The entrapment efficiency of the optimized formulation was found to be high, and in vitro release studies demonstrated a sustained and controlled release of paclitaxel. Drug-polymer compatibility was confirmed via FTIR studies, indicating no significant chemical interaction. Stability studies showed that the nanoparticles maintained their physicochemical properties over 90 days at 4°C and 25°C. The results suggest that the optimized paclitaxel-loaded PLGA nanoparticles possess the potential for improved anticancer therapy through enhanced bioavailability, sustained drug release, and targeted delivery.
Keywords: Poly(lactic-co-glycolic acid) (PLGA), FTIR Studies, Nanoprecipitation method, In vitro drug release studies
Cite This Article:
Please cite this article in press Nansri Saha et al., Design, Prepare And Optimization Of Plga Nanoparticles Loaded Paclitaxel , Indo Am. J. P. Sci, 2026; 13(01).
REFERENCES:
1. Pradesh T.S., Sunny C.M., Varma K.H., Ramesh P., Preperationn of microstuctured hydroxyapatite microspheres using oil in water emulsion, Bull Matter.Sci. 2005; 28(5):383-390.
2. Schugens C., Larvelle. N., Nihantn., Grandfils C., Jerome R. and Teyssie. P. J.Control.Rel.32, 1994, 161- 167.
3. Ishida, M; Nambu, N.and Nagai, T. “Highly viscous gel ointment containing carbapol for application to the oral mucosa”. Chem..pharm Bull., 31, (1983a) ,4561.
4. Collins, A.E and Deasy, P.B “Bioadhesive lozenge for improved deliveryof cetypyridinium chloride”.J.pharm.Sci.3(1), 1990, 5 – 9
5. Save T. and Venkatachalam P. “Bioadhesive tablets of Nifedipine: Standardization of a novel buccoadhesive erodible carrier”. Drug Dev.Ind. pharm., 20(19), 1994, 3005-3014.
6. Dev rajan,P.V;Gupta S.; Gandhi A.S.; Niphadkar,P.V. and Shah. “Trans mucosal drug delivery systems of Salbutamol Sulfate.” 26th Int.Symp. Control.Rel.Bioact.Mater., 1999,650.
7. Lopez, C.R; Portero, A.; Vila-Jato, J.C. and Alonso, M.J. “Design and Evaluation of Chitosan/Ethylcellulose mucoadhesive bilayered devices for buccal drug delivery.”J.control.Rel., 55, 1998, 143-152.
8. Parodi, B.; Russo, E.; Caviglioli, G.; Cafaggi, S.and Binardi, G. “Development &characterization of a buccoadhesive dosage from of Oxydodone hydrochloride”. Drug Dev.Ind.pharm., 22(5), 1996,445-450.
9. Chien, Y.W.; Corbo, D.C. and Liv, J.C. “Mucosal delivery of progestational Steroids from a Controlled release device: in vitro/in vivo relationship.”Drug Dev.Ind.pharm., 17(17), 1991, 2269-2290.
10. Zielińska, A.; Carreiró, F.; Oliveira, A.M.; Neves, A.; Pires, B.; Venkatesh, D.N.; Durazzo, A.; Lucarini, M.; Eder, P.; Silva, A.M.; et al. Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology. Molecules 2020, 25, 3731.
11. Ankit, Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention, March 2012, 4(4):1557-1562.
12. Betala S, Mohan Varma M, Abbulu K. Formulation and evaluation of polymeric nanoparticles of an antihypetensive drug for gastroretention. JDDT [Internet]. 15Nov.2018 ;8(6):82-6.
13. Marzouk. M., El bakry. AM., El hosary. R M.,Abd El Rahman. NK. Formulation and Evaluation of Polymeric Nanoparticles Based Transdermal Hydrogel of Terbutaline Sulphate. Azhar International Journal of Pharmaceutical and Medical Sciences, 2023; 3(2):20-29.
14. Ramesh C Nagarwal, Devendra N Ridhurkar, J K Pandit. In-vitro release kinetics and bioavailability of gastroretentive cinnarizine HCl tablet. AAPS PharmaSci Tech. 2010; 11(1): 294-303.
15. Bhargav Bhongiri*, Vadivelan Ramachandran, and Raman Suresh Kumar. “Preformulation Studies of S-Equol.” Journal of Pharmaceutical Negative Results, 2022, 1020-1029.IF-0.654.
16. Bhargav Bhongiri*, Vadivelan Ramachandran, Bharathi Bathula, Nagarani Racha, Development and characterisation of fenofibrate-loaded nanoparticles, International Journal of Advanced Research In Medical & Pharmaceutical Sciences, 2021, Volume.6, Issue.4.