Volume : 13, Issue : 07, July – 2026

Title:

FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF DICLOFENAC TRANSDERMAL PATCHES

Authors :

Bushra Naazneen, Dr. Abdul Sayeed, Dr. Faizan Sayeed,Dr. Syed Areefulla Hussainy

Abstract :

Different polymeric Patches containing Diclofenac were prepared and evaluated for physicochemical, in vitro drug release and Kinetic studies. The IR spectral analysis of Diclofenac showed that the principal peaks and for the mixture of Diclofenac with different polymers additional to the principal peaks, some additional peaks were observed with physical mixtures, which could be due to the presence of polymers. The presence of all the characteristic bands due to functional groups in polymer mixtures suggests that there is no interaction between the drug and polymers used in the present study. Diclofenac transdermal Patches with penetration enhancers Dimethyl Sulfoxide and 15%v/w propylene glycol used as plasticizer were prepared and evaluated for physicochemical and permeation characteristics. The prepared transdermal patches were evaluated for their physiochemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance; moisture content, drug content were suitable. Transdermal patches with ERS 100 and HPMC E15 showed better release than patches with ERL 100 and HPMC E15. The release rate was increased with an increase in HPMC E15 content. The release kinetics of the optimized formulations followed zero order and release mechanism was non-fickian diffusion rate-controlled mechanism. The research work gives a rational guideline for formulating a controlled release transdermal delivery system Df7 for effective therapy. The transdermal patches of Diclofenac with required flux could be prepared with suitable mechanical properties, further studies are recommended to find their therapeutic utility in humans by pharmacokinetic and pharmacodynamic studies.
Key Words: Transdermal patches, Diclofenac, ERS 100, HPMC E15.

Cite This Article:

Please cite this article in press Bushra Naazneen et al., Formulation, Development And In-Vitro Evaluation Of Diclofenac Transdermal Patches, Indo Am. J. P. Sci, 2026; 13(07).

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