37.Issue 07 july 26 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 13, Issue : 07, July – 2026

Title:

SYNERGISTIC THERAPEUTIC EFFECTS OF ALANGIUM SALVI FOLIUM, TINOSPORA CORDIFOLIA, TERMINALIA CHEBULA, AND PAVONIA ZEYLANICA IN A POLYHERBAL TABLET FORMULATION

Authors :

Karthik Gummadavelli, Dr. Manish Kumar Mishra, Dr. CH. Suresh

Abstract :

In Diabetes mellitus, chronic hyperglycemia, insulin failure, dyslipidemia, and inflammation result in substantial microvascular and macrovascular effects. The present work involves the development and evaluation of a polyherbal film-coated tablet prepared from ethanolic extracts of Alangium Salvi folium, Tinospora cordifolia, Terminalia chebula and Pavonia zeylanica for antidiabetic, anti-inflammatory and antihyperlipidemic activities. Phytochemical screening of produced plant extracts of ethanol and formulation in optimal film coated tablet (F8) was performed. The pharmacological effectiveness of the formulation was evaluated in streptozotocin-induced diabetic Wistar rats by assessing fasting blood glucose, serum insulin, HbA1c, oral glucose tolerance, total protein, pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and serum lipid profile. The optimized formulation exhibited dosage dependent therapeutic efficacy with 500 mg/kg showing similar results as that of Glibenclamide. The formulation significantly reduced fasting blood glucose, HbA1c, TNF-α, IL-6, IL-1β, total cholesterol, LDL cholesterol, triglycerides and VLDL cholesterol and increased serum insulin, HDL cholesterol, protein and glucose tolerance (p < 0.001). The pharmacological effects may be attributed to the synergistic impact of flavonoids, phenolic compounds, tannins, alkaloids, terpenoids, and other bioactive phytoconstituents present in the selected medicinal plants. Polyherbal film coated tablet demonstrated strong antidiabetic, anti-inflammatory and antihyperlipidemic actions indicating the safe and efficient herbal remedy for diabetes mellitus and associated metabolic consequences. Toxicology, pharmacokinetics, molecular processes and clinical efficacy studies should validate its therapeutic potential for people.
Keywords: Diabetes mellitus; Polyherbal formulation; Film-coated tablet; Alangium Salvi folium; Tinospora cordifolia; Terminalia chebula; Pavonia zeylanica; Streptozotocin-induced diabetes; Antidiabetic activity; Anti-inflammatory activity; Antihyperlipidemic activity; Phytoconstituents.

Cite This Article:

Please cite this article in press Karthik Gummadavelli et al., Synergistic Therapeutic Effects Of Alangium Salvi Folium, Tinospora Cordifolia, Terminalia Chebula, And Pavonia Zeylanica In A Polyherbal Tablet Formulation, Indo Am. J. P. Sci, 2026; 13(07).

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