Volume : 13, Issue : 07, July – 2026
Title:
FORMULATION AND EVALUATION OF TOPICAL HYDROGEL OF ANTI-INFLAMMATORY DRUG
Authors :
Yash Sanjay Uke, Mohd Bilal Sufi, Mudabbirul Haque
Abstract :
Piroxicam is a potent non-steroidal anti-inflammatory drug (NSAID) widely used in the management of pain and inflammatory disorders. However, its oral administration is often associated with gastrointestinal adverse effects and variable bioavailability. The present study aimed to formulate and evaluate a piroxicam-loaded topical hydrogel to provide sustained drug release and improved patient compliance. Hydrogels were prepared using Carbopol 934P, HPMC K4M, and sodium alginate along with suitable co-solvents and excipients. The prepared formulations were evaluated for physical appearance, homogeneity, pH, viscosity, spreadability, extrudability, drug content, and in vitro drug release. All formulations exhibited satisfactory physicochemical properties and were suitable for topical application. Among the developed formulations, batch F3 demonstrated optimum viscosity, excellent spreadability, uniform drug content, and controlled drug release. Stability studies confirmed the formulation remained stable under storage conditions. The study concluded that the optimized piroxicam hydrogel is a promising topical drug delivery system for effective and sustained management of pain and inflammation.
Keywords: Piroxicam, Hydrogel, Topical Drug Delivery, Carbopol 934P, HPMC K4M, Sodium Alginate, Sustained Drug Release, Anti-inflammatory, NSAID, Topical Gel.
Cite This Article:
Please cite this article in press Yash Sanjay Uke et al., Formulation And Evaluation Of Topical Hydrogel Of Anti-inflammatory Drug, Indo Am. J. P. Sci, 2026; 13(07).
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