Volume : 13, Issue : 07, July – 2026
Title:
DRUG-INDUCED COAGULOPATHY SECONDARY TO WARFARIN–ANTIBIOTIC INTERACTION: A CASE REPORT
Authors :
Asma Anjum, Heeba Fatima, Fouzia KhanM, Ayesha Batool
Abstract :
Drug-induced coagulopathy is a clinically significant adverse drug reaction that may lead to serious bleeding complications. Warfarin, owing to its narrow therapeutic index, is highly susceptible to drug interactions. We report a case of a 68-year-old male on chronic warfarin therapy who developed severe coagulopathy following the administration of ceftriaxone for respiratory infection. The patient presented with gum bleeding and hematuria, with a markedly elevated international normalized ratio (INR) of 7.8. Prompt discontinuation of warfarin, administration of vitamin K and fresh frozen plasma, and supportive care led to clinical improvement. This case highlights the importance of monitoring coagulation parameters and recognizing potential drug interactions in patients receiving anticoagulant therapy.
Keywords
Drug-induced coagulopathy, Warfarin, INR, Drug interaction, Bleeding
Cite This Article:
Please cite this article in press Asma Anjum et al., Drug-Induced Coagulopathy Secondary To Warfarin–Antibiotic Interaction: A Case Report, Indo Am. J. P. Sci, 2026; 13(07).
REFERENCES:
1. Holbrook AM, et al. Evidence-based management of anticoagulant therapy. Chest.
2. Hirsh J, Fuster V. Guide to anticoagulant therapy. Circulation.
3. Ansell J, et al. Managing oral anticoagulant therapy. Am J Med.
4. Ageno W, et al. Oral anticoagulant therapy guidelines. Chest.
5. Schelleman H, et al. Warfarin-antibiotic interactions and bleeding risk. Clin Pharmacol.