Volume : 13, Issue : 06, June – 2026
Title:
FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE BUCCAL FILMS BY SOLVENT CASTING METHOD
Authors :
Afreen Banu*,Dr.T.Mangilal,K. Anusha, Shaista Kabeer, C. Shirisha, Ishrath Begum
Abstract :
Buccal films (mucoadhesive) are a novel approach for the development of orally disintegrating dosage forms. They are thin, elegant in appearance and can be made into various sizes and shapes like rectangular or circular. The strips may be flexible or brittle, opaque or transparent. Buccal films are made up of various hydrophilic and hydrophobic polymers to provide rapid disintegration on the tongue without the need for water. The aim of the present study is to develop Buccal films of Tramadol Hydrochloride by enhancing drug dissolution in the oral cavity. The development of the films decreases the analgesic effect in less time and increases the patient’s compliance. Tramadol Hydrochloride films were prepared using Hydroxy propyl methyl cellulose-E5, Hydroxy propyl methyl cellulose-E6, Hydroxy propyl methyl cellulose-E15 and sodium alginate as polymers. Therefore, the prepared films were evaluated for various parameters like physical appearance and surface texture of the film, thickness of the film, folding endurance, moisture uptake, uniformity of weight and drug content, swelling index, in vitro disintegration studies, and in vitro dissolution studies. Stability studies were also performed. Though all the formulations equally passed the evaluation parameters, it is concluded that buccal films containing 400 mg of sodium alginate as the polymer because of better dissolution profile.
Keywords: Oral fast dissolving films, Tramadol Hydrochloride, Solvent casting method, Opioid analgesic.
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