Volume : 13, Issue : 06, June – 2026
Title:
DEVELOPMENT AND EVALUATION OF APIXABAN BUCCAL TABLETS FOR ENHANCED BIOAVAILABILITY
Authors :
Shaik Zishan Munap, Sangle G.P.*
Abstract :
The present study was aimed at the formulation and evaluation of buccal tablets of Apixaban using different concentrations of polymers to achieve controlled drug release. A total of eight formulations (F1–F8) were prepared and evaluated for preformulation, physicochemical, and in vitro performance characteristics. FTIR studies indicated no significant interaction between the drug and excipients, demonstrating compatibility. Pre-compression parameters revealed good flow properties of the powder blends. Post-compression evaluation of tablets showed that all formulations complied with pharmacopoeial limits for weight variation, hardness, friability, thickness, drug content, and swelling index. In vitro dissolution studies demonstrated sustained drug release for all formulations, with formulation F5 showing the highest release of 98.69% at 8 hours. Drug release kinetics revealed that the optimized formulation followed zero-order and Higuchi models, indicating a controlled and diffusion-based release mechanism. Stability studies conducted for 90 days under accelerated conditions showed no significant changes in drug release or physical characteristics. In conclusion, the optimized formulation (F5) of Apixaban buccal tablets exhibited satisfactory physicochemical properties, controlled drug release, and good stability, suggesting its potential as an effective alternative drug delivery system for improved therapeutic efficacy and patient compliance.
Keywords: Apixaban, Buccal tablets, FTIR Studies, Polymers, Sustained release, Drug release kinetics, Stability studies
Cite This Article:
Please cite this article in press Sangle G.P et al., Development And Evaluation Of Apixaban Buccal Tablets For Enhanced Bioavailability.., Indo Am. J. P. Sci, 2026; 13(06).
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