Volume : 13, Issue : 06, June – 2026

Title:

FORMULATION AND IN-VITRO EVALUATION OF FOSINOPRIL FAST DISSOLVING FILMS

Authors :

D.Anand Kumar, Srikala Kamireddy*

Abstract :

Objective: The present study was undertaken to develop fast dissolving oral films of fosinopril with the aim of enhancing patient compliance and achieving rapid drug release. Oral films provide an attractive alternative to conventional solid dosage forms, particularly for pediatric, geriatric, and dysphagic patients.
Methods: Fast dissolving oral films containing fosinopril were prepared by the solvent casting technique using different film-forming polymers, namely guar gum, xanthan gum, hydroxypropyl methylcellulose (HPMC E6), and polyvinyl alcohol (PVA). Eight formulations (F1–F8) were designed by varying polymer concentrations. Compatibility between the drug and excipients was investigated using Fourier Transform Infrared (FTIR) spectroscopy. The prepared films were evaluated for weight variation, thickness, tensile strength, folding endurance, disintegration time, mouth dissolving time, drug content, and in vitro drug release characteristics.
Results: All formulations exhibited satisfactory physicomechanical properties and acceptable drug content uniformity. Folding endurance values ranged from 32 ± 2.08 to 46 ± 3.60 folds, indicating adequate flexibility and mechanical resistance. Among the prepared formulations, F5 containing 2% w/v HPMC E6 demonstrated the most desirable characteristics with a disintegration time of 33.33 ± 3.05 seconds and a mouth dissolving time of 40.66 ± 3.04 seconds. The formulation showed a maximum drug release of 97.2% and maintained its stability under accelerated and long-term storage conditions.
Conclusion: The findings suggest that fast dissolving oral films of fosinopril can be successfully prepared by the solvent casting method. The optimized formulation exhibited rapid drug release, satisfactory mechanical properties, and good stability, making it a promising alternative to conventional oral dosage forms.
KEYWORDS: Fosinopril, Fast Dissolving Oral Film, Solvent Casting, HPMC E6, Drug Release, Patient Compliance.

Cite This Article:

Please cite this article in press Srikala kamireddy et al Formulation And In-Vitro Evaluation Of Fosinopril Fast Dissolving Films, Indo Am. J. P. Sci, 2026; 13(06).

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