Volume : 13, Issue : 06, June – 2026

Title:

ROLE OF POLYMERS IN COLON-SPECIFIC DRUG DELIVERY SYSTEMS

Authors :

Velpula Tharunya, Rachuri Yashwanth, Md.Asraf, Bandari Shyamala , Chandrasekhara Rao Baru*

Abstract :

Colon-specific drug delivery systems (CDDS) are designed to deliver drugs selectively to the colon, improving therapeutic efficacy and minimizing systemic side effects. These systems utilize pH-dependent, time-dependent, microbial-triggered, and pressure-controlled mechanisms of the polymers in delivering the drug. Polymers play a crucial role in drug protection and release. In this article we discuss the colon specific drug delivery systems and its approaches briefly.
Keywords: Colon specific drug delivery systems, polymers, pH dependent systems, time dependent systems.

Cite This Article:

Please cite this article in press Velpula Tharunya et al., Role Of Polymers In Colon-Specific Drug Delivery Systems, Indo Am. J. P. Sci, 2026; 13(06).

REFERENCES:

S. Amidon , J. E. Brown and V. S. Dave , AAPS PharmSciTech, 2015, 16 , 731 —741 CrossRef CAS PubMed .
L. E. McCoubrey , A. Favaron , A. Awad , M. Orlu , S. Gaisford and A. W. Basit , J. Controlled Release, 2023, 353 , 1107 —1126 CrossRef CAS PubMed .
J. B. Dressman , R. R. Berardi , L. C. Dermentzoglou , T. L. Russell , S. P. Schmaltz , J. L. Barnett and K. M. Jarvenpaa , Pharm. Res., 1990, 7 , 756 —761 CrossRef CAS PubMed .
V. C. Ibekwe , H. M. Fadda , E. L. McConnell , M. K. Khela , D. F. Evans and A. W. Basit , Pharm. Res., 2008, 25 , 1828 —1835 CrossRef CAS PubMed .
S. Amidon , J. E. Brown and V. S. Dave , AAPS PharmSciTech, 2015, 16 , 731 CrossRef CAS PubMed .
S. Moutaharrik , A. Maroni , A. Melocchi , L. Zema , A. Foppoli , M. Cerea , L. Palugan , C. Neut , F. Siepmann , J. Siepmann and A. Gazzaniga , J. Drug Deliv. Sci. Technol., 2021, 66 , 102919 CrossRef CAS .
U. Mahadevan Clin. Colon Rectal Surg., 2004, 17 , 7 CrossRef PubMed .
S. Özdemir , B. Üner , J. Baranauskaite , E. Sümer , E. Yıldırım and A. Yaba , Eur. J. Pharm. Biopharm., 2023, 187 , 34 —45 CrossRef PubMed .
A. Deljavan Ghodrati and T. Comoglu , An overview on recent approaches for colonic drug delivery systems, Pharm. Dev. Technol., 2024, 29 , 566 —581 CrossRef CAS PubMed .
A. Parihar , V. R. Chidrawar , S. Singh , B. Basu , S. Pal , P. L. Pingale , H. Paliwal and B. G. Prajapati , Novel targeting formulations in colorectal cancer, Colorectal Cancer , Academic Press, 2024, vol. 1, pp. 175–201 Search PubMed .
F. Re , S. Pelucchi , F. Pettini , A. Prantera , F. Troisi , R. M. Mahmoud , R. Giovannoni and D. Barisani , Emerging nanocarrier systems for the enhanced delivery of active pharmaceutical ingredients to the intestine, Nanomedicine, 2025, 29 , 1 —24 Search PubMed .
A. K. Philip and B. Philip , Oman Med. J., 2010, 25 , 79 CrossRef PubMed .
M. Zhang and D. Merlin , Inflamm. Bowel Dis., 2018, 24 , 1401 CrossRef PubMed .
I. Khan , N. Ullah , L. Zha , Y. Bai , A. Khan , T. Zhao , T. Che and C. Zhang , Pathogens, 2019, 8 , 126 CrossRef CAS PubMed .
G. G. Kaplan Nat. Rev. Gastroenterol. Hepatol., 2015, 12 , 720 —727 CrossRef PubMed .
J. F. Coelho , P. C. Ferreira , P. Alves , R. Cordeiro , A. C. Fonseca , J. R. Góis and M. H. Gil , EPMA J., 2010, 1 , 164 —209 CrossRef PubMed .
A. J. Coupe , S. S. Davis and I. R. Wilding , Pharm. Res., 1991, 8 , 360 —364 CrossRef CAS PubMed .
R. Malayandi , P. K. Kondamudi , P. K. Ruby and D. Aggarwal , Drug Deliv. Transl. Res., 2014, 4 , 187 —202 CrossRef CAS PubMed .
A. Bhutto and J. E. Morley , Curr. Opin. Clin. Nutr. Metab. Care, 2008, 11 , 651 —660 CrossRef CAS PubMed .
I. Dumic , T. Nordin , M. Jecmenica , M. Stojkovic Lalosevic , T. Milosavljevic and T. Milovanovic , Gastrointestinal tract disorders in older age, Can. J. Gastroenterol. Hepatol., 2019, 2019 , 6757524 Search PubMed .
Y. J. Zhang , S. Li , R. Y. Gan , T. Zhou , D. P. Xu and H. Bin Li , Int. J. Mol. Sci., 2015, 16 , 7493 —7519 CrossRef CAS PubMed .
I. Rowland , G. Gibson , A. Heinken , K. Scott , J. Swann , I. Thiele and K. Tuohy , Eur. J. Nutr., 2017, 57 , 1 —24 CrossRef PubMed .
S. Maher and D. J. Brayden , Adv. Drug Deliv. Rev., 2021, 177 , 113925 CrossRef CAS PubMed .
G. Chen , W. Kang , W. Li , S. Chen and Y. Gao , Theranostics, 2022, 12 , 1419 —1439 CrossRef CAS PubMed .
P. R. Kiela and F. K. Ghishan , Best Pract. Res. Clin. Gastroenterol., 2016, 30 , 145 CrossRef CAS PubMed .
S. Adepu and S. Ramakrishna , Molecules, 2021, 26 , 5905 Search PubMed .
I. I. Ahmed Juvale , A. A. Abdul Hamid , K. B. Abd Halim and A. T. Che Has , Heliyon, 2022, 8 , e09777 CrossRef CAS PubMed .
R. Arévalo-Pérez , C. Maderuelo and J. M. Lanao , J. Controlled Release, 2020, 327 , 703 —724 CrossRef PubMed .
C. Stillhart , K. Vučićević , P. Augustijns , A. W. Basit , H. Batchelor , T. R. Flanagan , I. Gesquiere , R. Greupink , D. Keszthelyi , M. Koskinen , C. M. Madla , C. Matthys , G. Miljuš , M. G. Mooij , N. Parrott , A. L. Ungell , S. N. de Wildt , M. Orlu , S. Klein and A. Müllertz , Eur. J. Pharm. Sci., 2020, 147 , 105280 Search PubMed .
L. L. Azzouz and S. Sharma , Physiology, large intestine, StatPearls , StatPearls Publishing, 2023, Search PubMed .
A. J. Coupe , S. S. Davis and I. R. Wilding , Pharm. Res., 1991, 8 , 360 —364 Search PubMed .
S. V. Rana , S. Sharma , A. Malik , J. Kaur , K. K. Prasad , S. K. Sinha and K. Singh , Dig. Dis. Sci., 2013, 58 , 2594 —2598 CrossRef CAS PubMed .
Z. Vinarov , M. Abdallah , J. A. G. Agundez , K. Allegaert , A. W. Basit , M. Braeckmans , J. Ceulemans , M. Corsetti , B. T. Griffin , M. Grimm , D. Keszthelyi , M. Koziolek , C. M. Madla , C. Matthys , L. E. McCoubrey , A. Mitra , C. Reppas , J. Stappaerts , N. Steenackers , N. L. Trevaskis , T. Vanuytsel , M. Vertzoni , W. Weitschies , C. Wilson and P. Augustijns , Eur. J. Pharm. Sci., 2021, 162 , 105812 CrossRef CAS PubMed .
J. W. Arkwright , A. Dickson , S. A. Maunder , N. G. Blenman , J. Lim , G. O’Grady , R. Archer , M. Costa , N. J. Spencer , S. Brookes , A. Pullan and P. G. Dinning , Neurogastroenterol. Motil., 2013, 25 , e52 CrossRef CAS PubMed .
C. Manichanh , N. Borruel , F. Casellas and F. Guarner , The gut microbiota in IBD, Nat. Rev. Gastroenterol. Hepatol., 2012, 9 , 599 —608 CrossRef CAS PubMed .
S. Hua Front. Pharmacol, 2020, 11 , 496058 Search PubMed .
A. K. Philip and B. Philip , Oman Med. J., 2010, 25 , 79 Search PubMed .
T. L. Carlson , J. Y. Lock and R. L. Carrier , Engineering the mucus barrier, Annu. Rev. Biomed. Eng., 2018, 20 , 197 —220 Search PubMed .
M. K. Chourasia and S. K. Jain , Pharmaceutical approaches to colon targeted drug delivery systems, J. Pharm. Pharmaceut. Sci., 2003, 6 , 33 —66 Search PubMed .
H. S. Sardou et al., Inflammopharmacology, 2023, 31 , 1095 —1105 CrossRef CAS PubMed .