Volume : 13, Issue : 03, March – 2026
Title:
DEVELOPMENT AND CHARACTERIZATION OF REBAMIPIDE LOADED GASTRO RETENTIVE FLOATING MICROSPHERE FOR ENHANCED GASTRIC RESIDENCE
Authors :
Mohammed Juned Singhaniya, Rahul Mathur, Dr. Jagdish Chandra Rathi
Abstract :
Rebamipide-loaded floating microspheres were successfully formulated and evaluated to develop a gastroretentive drug delivery system with improved retention and controlled release. Preformulation studies confirmed the physicochemical identity of Rebamipide, obtained as a white powder with a melting point of 290–292°C. Solubility analysis across multiple solvents and FT-IR characterization verified drug purity and compatibility with ethyl cellulose and HPMC, ensuring excipient safety. Analytical validation demonstrated linearity in the concentration range of 2–10 µg/mL with a regression equation of y = 0.064x + 0.002, confirming method reliability. Formulations F1–F6 were prepared and evaluated for percentage yield, drug entrapment efficiency, buoyancy and floating lag time. Among all batches, F5 exhibited the highest percentage yield (86.65 ± 0.52%), maximum drug entrapment efficiency (83.32 ± 0.65%), shortest floating lag time (48 ± 5 sec), and greatest buoyancy (84.25 ± 0.27%). Particle size analysis of F5 indicated microspheres (231.4 nm) with uniform distribution, while zeta potential (12.2 mV) suggested moderate stability supported by steric hindrance of polymers. In-vitro drug release studies demonstrated biphasic release with initial rapid release followed by sustained release up to 96.85% at 12 hours, fitting the Peppas–Korsmeyer kinetic model. Stability studies under accelerated conditions of formulation F5. Overall, optimized formulation (F5) demonstrated reproducible preparation, high yield, excellent drug entrapment, nanoscale particle size and superior floating behavior, making it a promising candidate for gastroretentive delivery of Rebamipide. These findings provide a strong foundation for further in vivo evaluation and clinical translation.
KEYWORDS: Rebamipide, Gastroretentive, microspheres buoyancy and floating, Preformulation
Cite This Article:
Please cite this article in press Mohammed Juned Singhaniya et al., Development And Characterization Of Rebamipide Loaded Gastro Retentive Floating Microsphere For Enhanced Gastric Residence., Indo Am. J. P. Sci, 2026; 13(03).
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