Volume : 13, Issue : 03, March – 2026

Title:

DESIGN AND DEVELOPMENT OF BUDESONIDE COLON SPECIFIC DRUG DELIVERY SYSTEM FOR INFLAMMATORY BOWEL DISEASE

Authors :

Dr. P. Sobitha Rani, Dr Fatima Shireen, B.Poojitha, C. Mounika, K.Vaishnavi, M. Madhuri, U. Poojitha

Abstract :

In present work Colon targeting drug delivery system was developed for Budesonide drug by using combination of delayed systems one is pH dependent and other is time dependent delayed system. Rapid release core tablet (RRCT) formulations were prepared using Budesonide drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F4 formulation with crospovidone was the best formulation. For optimized formulation press coat was done by using Guar gum and Eudragit in different ratios. Press coated tablet delays the drug release up to 8 hours based on the nature and concentrations of the polymer. As a result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner.
Keywords: Colon specific, Budesonide, FTIR studies, Natural polymers, Coating tablets, In vitro drug release studies

Cite This Article:

Please cite this article in press P. Sobitha Rani et al., Design And Development Of Budesonide Colon Specific Drug Delivery System For Inflammatory Bowel Disease., Indo Am. J. P. Sci, 2026; 13(03).

REFERENCES:

1. Philip, A. K., & Philip, B. (2010). Colon targeted drug delivery systems: A review on primary and novel approaches. Oman Medical Journal, 25(2), 79–87.
2. Chourasia, M. K., & Jain, S. K. (2003). Pharmaceutical approaches to colon targeted drug delivery systems. Journal of Pharmaceutical Sciences, 92(4), 673–687.
3. Sinha, V. R., Kumria, R. (2001). Microbially triggered drug delivery to the colon. European Journal of Pharmaceutical Sciences, 18(1), 3–18.
4. Friend, D. R. (2005). New oral delivery systems for treatment of inflammatory bowel disease. Advanced Drug Delivery Reviews, 57(2), 247–265.
5. Lamprecht, A., Yamamoto, H., Takeuchi, H., & Kawashima, Y. (2003). Microsphere design for the colonic delivery of budesonide. Journal of Controlled Release, 90(3), 313–322.
6. Edwards, C. M., & Daly, A. K. (1995). Budesonide: pharmacology and clinical application in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 9(4), 349–359.
7. Macleod, G.S., Fell, J.T., Collett, J.H., Sharma, J.L., Smith, A.M. (Selective drug delivery to the colon using pectin, chitosan, hydroxypropyl methylcellulose film coated tablets). Int. J. Pharm. 1999, 187,251–257.
8. Wei H, Qing D, De-Ying C, Bai X, Fanli-Fang.PDA Pectin/Ethylcellulose as film coatings for colon-specific drug delivery: preparation and in vitro evaluation using 5-fluorouracil pellets. J Pharm Sci Technol. 2007 Mar-Apr;61(2):121-30.
9. Kotagale N, Maniyar M, Somvanshi S, Umekar M, Patel Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. CJ.Pharm Dev Technol. 2010 Jul-Aug;15(4):431-7.
10. Hsu FY, Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery. 2013 Feb;24(2):317-23. Epub 2012 Oct 27.
11. Thakral S, Thakral NK, Majumdar Colon targeted drug delivery systems–an overview. DK.Expert Opin Drug Deliv. 2013 Jan;10(1):131-49. Epub 2012 Oct 26.
12. Minko T. Drug targeting to the colon with lectins and neoglycoconjugates. Adv Drug Deliv Rev 2003;56:491–509.
13. Fukui E, Miyamura N, Uemura K, Kobayashi M. Preparation of enteric coated timed-release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting. Int J Pharm 2000;204:7–15.
14. Liu L, Fishman ML, Kost J, Hicks KB. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003;24:3333–3343.
15. Yang L, Chu JS, Fix JA. Colon-specific drug delivery: New approaches and in vitro/in vivo evaluation. Int J Pharm 2002;235:1–15. Pitarresi G, Casadei MA, Mandracchia D, Paolicelli P, Palumbo FS, Giammona G. Photo-cross linking of dextran and polyaspartamide derivatives: A combination suitable for colon-specific drug delivery. J Control Release 2007;119:328–338.
16. Azarmi S, Farid J, Nokhodchi A, Bahari-Saravi SM, Valizadeh H. Thermal treating as a tool for sustained release of Indomethacin from Eudragit RS and RL matrices. Int J Pharm 2002;246:171–177.