Volume : 13, Issue : 03, March – 2026
Title:
FORMULATION AND EVALUATION OF MICRO SPHERES OF DILTIAZEM HYDROCHLORIDE
Authors :
O.Girija*, J N Suresh Kumar, SK.mahaboob Subhani, K.Sarika, S.Ramya, S.Sumathi, U.Sai Krishna
Abstract :
Microspheres of diltiazem hydrochloride were formulated using combination of HPMC and Eudragit RS 100 and Eudragit RS 100 alone by solvent evaporation and nonsolvent addition methods with aim to prolong its release. Six formulations prepared by using different drug;polymer ratios were evaluated for percentage entrapment .loading efficiency, percentage of encapsulation, particle size distribution, scanning electron microscopy, Differential scanning colorimetry infrared spectroscopy, dissolution studies and compared with marketed SR capsules. Depending upon the drug to polymer ratio, the entrapment, loading and encapsulation were found to be 77.45±0.22 to 91.08 ±0.62%,34.76± 0.15 to 52.46±0.25% and 66.09± 0.19 to 82.70 ±0.57 respectively. The microspheres were spherical, discrete and compact and size ranged between 4μm to 24μm. Invitro studies were carried out at different pH for a period of 12 hours and compared with marketed formulation (SR). First order of drug release was followed by formulations using the combination of the retardants and zero order for preparations containing Eudragit RS 100 alone The analysis of regression values of Higuchi plot and koyser-peppas plot and “n” values of koyser – peppas model shows a combination of diffusional and dissolutional mechanism indicating the drug release from the formulations is controlled by more than one process.Results of FTIR and DSC proves that drug polymer interaction was absent. Invivo pharmacokinetic study of the formulation proved that prolongation of drug release is obtained by formulating as micro spheres.
Cite This Article:
Please cite this article in press O.Girija et al., Formulation And Evaluation Of Micro Spheres Of Diltiazem Hydrochloride., Indo Am. J. P. Sci, 2026; 13(03).
REFERENCES:
1. Ahmed V., Sharma S., Bhatt P. Formulation and Evaluation of Sustained Release Tablet of Diltiazem Hydrochloride. Int. J. Pharm. Sci. Res. 2020;11:2193-2199.
2. Kavishetti R., Halkeri M., Nargund S.L., Shahapur A. Formulation and Evaluation of Mucoadhesive Tablets of Diltiazem Hydrochloride. World J. Pharm. Pharm. Sci. 2024;13:1022–1037.
3 .Allaboun H., Alkhamis K.A., Al-Nimry S.S. Preparation of Sustained Release Formulation of Verapamil Hydrochloride Using Ion Exchange Resins. AAPS PharmSciTech. 2023;24:1–10.
4. Subedi G., Shrestha A.K., Shakya S. Study of Effect of Different Factors in Formulation of Micro and Nanospheres with Solvent Evaporation Technique. Open Pharm. Sci. J. 2016;3:182–195.
5. Sahoo J., Mishra B., Kumar Biswal P., Dixit P.K. Formulation, Evaluation and in-Vitro Release Study of Diltiazem Hcl Loaded Gelatinous Microsphere. Biopharm. J. 2016;2016:27–33.
6. Krishan B.V., Rao C.B., Kishore V.S. Design and Development of Pulsatile Drug Delivery of Diltiazem Hydrochloride. Res. J. Pharm. Tech. 2020;13:2315..
7. Kalidindi DV: Microspheres of diltiazem hydrochloride by ionotropic gelation technique. Int J Pharm Sci Res 2017; 8(3): 1413-19.
8. Gupta MK, Khunteta A, Optimization of the release kinetics of diltiazem hydrochloride from tableted microspheres, Journal of Drug Delivery and Therapeutics. 2018; 8(1):57-63.
9. U.D. Shivhare, S.B. Patel. Emulsification-Internal Gelation Technique for Formulation and Evaluation of Mucoadhesive Microspheres of Diltiazem Hydrochloride. Research J. Pharm. and Tech. 2011; 4(9): 1422-1427.