Volume : 13, Issue : 03, March – 2026
Title:
HERBOSOMES – A NOVEL DRUG DELIVERY CARRIER FOR ENHANCED BIOAVAILABILITY OF HERBAL EXTRACTS
Authors :
V. Anusha*, R. Kusuma, B. Swathi, N. Rajani, Aruna Kuthani
Abstract :
Herbal treatments also consistently and significantly contribute to the development of human health in comparison with allopathic treatments. From ancient times, herbal preparations were considered as the most essential type of medicine in all the civilizations. The numerous plant extracts have exhibited an extensive range of biological activity, like immunomodulator activity, hepatoprotective activity, antilipidemic action, etc. Herbal extracts obtained from plants demonstrate great in vitro bioactivity and exhibits low in vivo action in animal models. The foremost explanations for this behavior is that the bioactive components have the composition that cannot be permeated by simple passive diffusion, and most of the phytoconstituents are polar water soluble compounds, which results in their poor lipid solubility. This issue can be resolved by formulation of herbosomes which are the novel lipid based drug delivery system which delivers the herbal extract at the targeted site of activity with improved absorption, bioavailability and efficacy. They assists to overcome the challenges of bioavailability issues by forming herbososme complex. They include complex comprising herbal natural extract with suitable phospholipids like phosphatidylcholine and phosphatidylserine, etc. This advanced technique has been developing as an approach to enhance the medicinal potential of plant based extracts.
Key words: Herbosomes, phospholipids, bioavailability, phytomedicines, phytoconstituents
systems
Cite This Article:
Please cite this article in press V Anusha et al., Herbosomes – A Novel Drug Delivery Carrier For Enhanced Bioavailability Of Herbal Extracts., Indo Am. J. P. Sci, 2026; 13(03).
REFERENCES:
1) Samiksha N. Ajankar, Pavan S. Dange, Akash C. Garudkar, Dr. Monika P. Jadhao. Herbosome: The most recent novel drug delivery system. International Journal of Creative Research thoughts. 2023; 11(4):123-130.
2) Deepak Kumar Dash, Anil Kumar Sahu, Vaibhav Tripathi, Yogesh Sahu. Herbosomes: A potent drug carrier. Journal of Pharmaceutical and Biological Sciences 2022; 10(1):44–46.
3) Shaikh Samrin Mohammad Tufail, Kashtriya Jayshri Prakash, Kazi Shifa Abdul Wadood. Formulation and Characterization of Herbosome: A Review. International Journal of Research in Pharmacy and Allied Science. 2025; 4 (5): 167-173.
4) Chetna Chauhan, Dr. Hariom Sharma, Dr. Rishi Kumar. A Comprehensive Review Article on Herbosomes. International Journal of Pharmaceutical sciences. 2025; 3 (4): 581-596.
5) Imdadul Haque Chaudhury, Pulak Deb, Sumit Das. A review on formulation and characterization of herbosome complex. International Journal of Current Pharmaceutical Research. 2019; 11(4): 42-46.
6) Ankur Choubey. Phytosome- A novel approach for herbal drug delivery. International Journal of Pharmaceutical sciences and research. 2011; 2(4): 804-815
7) Maiti, K, Mukherjee K, Gantait A, Nazeer Ahamed H, Saha, B.P, Kumar Mukherjee P. Enhanced therapeutic benefit of quercetin phospholipid complex in carbon tetrachloride-induced acute liver injury in rats: a comparative study Iranian Journal of Pharmacology and Therapeutics. 2005; 4(2): 84-90.
8) Prachi Udapurkar, Omprakash Bhusnure, Santosh Kamble and Kailash Biyani. Phyto-phospholipid complex vesicles for phytoconstituents and herbal extracts: A promising drug delivery system. International Journal of Herbal Medicine 2016; 4(5): 14-20.
9) Nayyer K, Babak G, Hamed H, Fatemeh K, Mohammad MG. Phytosome as novel delivery system for nutraceutical materials. International Journal of Current Microbiology and Applied Sciences. 2015; 4(6):152-159.
10) Monica G. and Vasu V. Naik. Herbosomes: A potential carriers for the bioavailability enhancement of herbal extracts. World journal of pharmacy and pharmaceutical sciences. 2014; 4(10):1052-1079.
11) Aysegul K, Faith T. Phyto-Phospholid Complex as Drug Delivery system For Herbal Extracts/molecules. Turkish Journal of Pharmaceutical science. 2015; 12(1):93-102.
12) Vandana Saini, Babita Rani, Manju Nagpal, Sandeep Arora. Phytosomes: potential carriers for herbal drugs. American journal of Pharmtech Research. 2013; 3(1):250-260.
13) Pallav Kaushik Deshpande, Anupam Kumar Pathak, Ragini Gothalwal. Phytosomes: A Noval Drug Delivery System for Phytoconstituents. Journal on New Biological Reports. 2014; 3(3):212-220.
14) Rajendra awasthi, Giriraj t kulkarni, Vivek k pawar. Phytosomes: an approach to increase the bioavailability of plant extracts, International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(2):1-3.
15) More MS, Shende MA, Kolhe DB, Jaiswal NM. Herbosomes: Herbo-phospholipid complex an approach for absorption enhancement. International Journal of Biological & Pharmaceutical Research. 2012; 3(8):946- 955.
16) Singh RP, Parpani S, Narke R, Chavan R. Phytosome: Recent Advance Research for Novel Drug Delivery System. Asian Journal of Pharmaceutical Research and Development. 2014; 2(3):15–29.
17) Tawheed A, Bhat SV. A review on phytosome technology as a novel Approach to improve the bioavailability of nutraceuticals. International Journal of Advancements in Research & Technology. 2012; 1(3): 1-15,
18) Gagandeep Mehta, Ritu Rani, Ajeet Pal Singh, Amar Pal Singh. Phytosomes: An Overview. International Journal of Pharmaceutics and Drug Analysis. 2024; 12(1): 65-71.
19) Priyanka Rathore, Gaurav Swami. Planterosomes: A potential Phyto-phospholipid carriers for the bioavailability enhancement of herbal extracts. International Journal of pharmaceutical sciences and research. 2012; 3(3):737-755.
20) Pandey Shivanand, Patel Kinjal. Phytosomes: Technical Revolution in Phytomedicine. International Journal of PharmTech Research. 2010; 2(1): 627-631.