Volume : 13, Issue : 05, May – 2026
Title:
FORMULATION AND EVALUATION OF MEDICATED JELLIES
Authors :
Mohammad Sabir P. Beniwale, Nandkishor B Deshmukh , Dr.Swati P Deshmukh
Abstract :
Oral drug delivery remains the most widely accepted route of administration due to its convenience, cost-effectiveness, and high patient compliance. However, conventional solid dosage forms such as tablets and capsules often pose swallowing difficulties, particularly for pediatric, geriatric, and dysphagic patients. The present study focuses on the formulation and evaluation of medicated jellies as an alternative oral drug delivery system to overcome these limitations. Medicated jellies are semi-solid, palatable formulations capable of improving patient acceptability while ensuring effective drug delivery.
In this study, medicated jellies containing amoxicillin and ibuprofen were formulated using suitable excipients such as gelatin, agar, tragacanth, sucrose, and citric acid. Different formulations were prepared by varying ingredient composition to optimize texture, stability, and drug release characteristics. The preparation involved dissolving sugar, incorporating gelling agents, addition of active pharmaceutical ingredients, followed by molding and setting.
The formulated jellies were evaluated for various physicochemical and organoleptic parameters, including appearance, taste, odor, pH, texture, weight variation, moisture content, and disintegration time. The results indicated that the formulations exhibited acceptable properties, with good stability and uniformity. Among the developed batches, optimized formulations demonstrated improved taste, texture, and overall patient acceptability.
Thus, medicated jellies represent a promising and patient-friendly drug delivery system, offering enhanced compliance and therapeutic effectiveness, especially for populations with swallowing difficulties.
Keywords:Medicated jellies, Oral drug delivery, Medicated Jelly, Herbal dosage form, Amoxicillin, Ibuprofen
Cite This Article:
Please cite this article in press Mohammad Sabir Piru Beniwale et al., Formulation And Evaluation Of Medicated Jellies, Indo Am. J. P. Sci, 2026; 13(05).
REFERENCES:
1. Allen LV, Popovich NG, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 11th ed. Philadelphia: Lippincott Williams & Wilkins; 2021.
2. Aulton ME, Taylor KMG. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines. 5th ed. London: Elsevier; 2018.
3. Choonara YE, Pillay V, Ndesendo VMK. Trends in oral drug delivery: Advances in polymer-based formulations and nanotechnology. J Drug Deliv Sci Technol. 2014;24(2):123–35. doi:10.1016/j.jddst.2013.09.002
4. Gupta PK, Robinson JR. Oral controlled-release drug delivery systems. Pharm Res. 2016;5(10):615–30. doi:10.1023/A:1015903405373
5. Kaur L, Gupta S, Tiwary AK. Mucoadhesive drug delivery: Mechanistic insights and applications. Int J Pharm. 2019;570:118642. doi:10.1016/j.ijpharm.2019.118642
6. Khan F, Imam SS. Advances in nanotechnology-based oral drug delivery: Challenges and prospects. Curr Pharm Des. 2022;28(5):742–58. Doi:10.2174/1381612828666220207110934
7. Kumar R, Patil MB. Medicated jelly formulations: A novel drug delivery system. J Appl Pharm Sci. 2017;7(11):157–66. doi:10.7324/JAPS.2017.7112
8. Patel SK, Sharma V. Buccal and sublingual drug delivery systems: An overview. Asian J Pharm. 2020;14(3):164–74. doi:10.22377/ajp.v14i3.3795
9. Prajapati SK, Tripathi P. A review on oral drug delivery systems: Innovations and advancements. Drug Dev Ind Pharm. 2016;42(7):1085–93. doi:10.3109/03639045.2016.1162173
10. Siepmann J, Siepmann F. Controlled release polymeric formulations: A new era in drug delivery. J Control Release. 2018;287:2–3.
11. Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ. Advances in oral drug delivery. Front Pharmacol. 2021;12:618411. doi:10.3389/fphar.2021.618411
12. Choonara YE, Pillay V, Ndesendo VMK. Trends in oral drug delivery: Advances in polymer-based formulations and nanotechnology. J Drug Deliv Sci Technol. 2014;24(2):123–35. doi:10.1016/j.jddst.2013.09.002
13. Gupta PK, Robinson JR. Oral controlled-release drug delivery systems. Pharm Res. 2016;5(10):615–30. doi:10.1023/A:1015903405373
14. Kaur L, Gupta S, Tiwary AK. Mucoadhesive drug delivery: Mechanistic insights and applications. Int J Pharm. 2019;570:118642. doi:10.1016/j.ijpharm.2019.118642
15. Khan F, Imam SS. Advances in nanotechnology-based oral drug delivery: Challenges and prospects. Curr Pharm Des. 2022;28(5):742–58.
16. Kumar R, Patil MB. Medicated jelly formulations: A novel drug delivery system. J Appl Pharm Sci. 2017;7(11):157–66. doi:10.7324/JAPS.2017.71124
17. Patel SK, Sharma V. Buccal and sublingual drug delivery systems: An overview. Asian J Pharm. 2020;14(3):164–74. doi:10.22377/ajp.v14i3.3795
18. Prajapati SK, Tripathi P. A review on oral drug delivery systems: Innovations and advancements. Drug Dev Ind Pharm. 2016;42(7):1085–101.
19. Siepmann J, Siepmann F. Controlled release polymeric formulations: A new era in drug delivery. J Control Release. 2018;287:2–3. doi:10.1016/j.jconrel.2018.09.003
20. Vyas SP, Khar RK. Controlled Drug Delivery: Concepts and Advances. 2nd ed. New Delhi: CBS Publishers & Distributors; 2017.
21. Allen LV, Popovich NG, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 11th ed. Philadelphia: Wolters Kluwer; 2020.
22. Aungst BJ. Intestinal permeation enhancers. Pharm Sci. 2013;102(10):3151–73.




