Volume : 13, Issue : 05, May – 2026

Title:

KNOWLEDGE AND PRACTICE OF PHARMACOGENOMICS AMONG PHARMACY STUDENTS: A CROSS-SECTIONAL STUDY

Authors :

Virat G. Rathod, Mr. Nandkishor B. Deshmukh, Dr. Swati P. Deshmukh

Abstract :

Oral hygiene plays a critical role in maintaining both oral and systemic health, as poor oral care is strongly associated with conditions such as dental caries, gingivitis, periodontitis, and halitosis, as well as systemic disorders including cardiovascular diseases, diabetes mellitus, and respiratory infections. Despite the widespread use of conventional oral care products, concerns have arisen regarding the safety and environmental impact of synthetic ingredients such as fluoride, triclosan, and Sodium Lauryl Sulfate (SLS), which may cause adverse health effects upon prolonged use. This has led to a growing demand for safer, natural, and eco-friendly alternatives.
The present study focuses on the formulation and evaluation of a herbal toothpaste incorporating key medicinal plant ingredients, namely Neem (Azadirachta indica), Clove (Syzygium aromaticum), and Turmeric (Curcuma longa), known for their antimicrobial, anti-inflammatory, and antioxidant properties. Additional components such as baking soda, salt, coconut oil, and peppermint oil were included to enhance cleansing efficiency, antimicrobial action, and user acceptability. A minimal and controlled amount of SLS was used to improve foaming characteristics without compromising safety.
The formulation was developed using standardized procedures to ensure uniformity, stability, and effectiveness. It was evaluated through physicochemical parameters including pH, spreadability, foaming capacity, and texture, along with antimicrobial activity, stability studies, and sensory evaluation. The results indicate that the herbal toothpaste demonstrates satisfactory performance in maintaining oral hygiene while offering a safer and environmentally sustainable alternative to conventional products.
This study highlights the potential of integrating traditional herbal knowledge with modern scientific approaches to develop effective, safe, and eco-friendly oral care solutions, thereby contributing to improved public health and sustainable healthcare practices.
Keywords:Herbal Toothpaste, Oral Hygiene, Neem, Clove, Turmeric, Antimicrobial Activity, Natural Formulation, Sustainable Healthcare, Sodium Lauryl Sulfate, Dental Care

Cite This Article:

Please cite this article in press Virat G. Rathod et al., Knowledge And Practice Of Pharmacogenomics Among Pharmacy Students: A Cross-Sectional Study, Indo Am. J. P. Sci, 2026; 13(05).

REFERENCES:

1. Gupta P, Agarwal V, Eswar P. Evaluation of the antimicrobial activity of herbal toothpaste and mouthwashes against Streptococcus mutans: An in vitro study. J Indian Assoc Public Health Dent. 2014;12(4):279-82.
2. Nagpal M, Sood S. Role of curcumin in systemic and oral health: An overview. J Nat SciBiol Med. 2013;4(1):3-7.
3. Senthilkumar KL, Venkateswaran S, Vasanthan A, Chiranjeevi P, Mohamed N,Dinesh S, et al. Formulation development and evaluation novel herbal toothpaste from natural source. Int J Pharm Chem Ana 2022;9(1):28-32. IJPCA.ORG
4. Nair R, Chanda S, Chanda R. Antibacterial activity of peppermint oil against oral pathogens. J Essent Oil Res. 2018;30(2):103-7.
5. Shaikh AA. Comparative evaluation of herbal toothpaste formulations: A preliminary study. Indian J Pharm Pharmacol. 2022;9(2):65-70. IJPP.ORG.IN
6. Kumar R, Singh P, Yadav M. Formulation and evaluation of herbal tooth powder. Journal of Emerging Technologies and Innovative Research (JETIR)
[Internet]. 2024 May [cited 2025 Mar 6];11 (5):87-92.
7. Balappanavar AY, Sardana V, Gupta K. Comparison of the effectiveness of a herbal and a non-herbal dentifrice on established gingivitis. J Indian SocPeriodontol. 2013;17(1):128-32.
8. Peedikayil FC, Sreenivasan P, Shingte BA, Pawar SM, Chavan PR. Herbal toothpaste: An overview. Int J Res Anal Rev. 2022;9(3):234-40.
15 Tein M. Mathur A, Mathur AD. Comparative evaluation of desensitizing toothpaste and fluoride varnish in reducing dentinal hypersensitivity. J ClinDiagn Res. 2019;13(3):ZC34ZC37.
16. Raut ID, Gumate DS, Patil SS, Patil VR. Formulation and evaluation of polyherbal toothpaste using medicinal plants. Int J Pharm Pharm Res.2020;20(1): 1-5.
17. Mangilal T, Ravikumar M. Preparation and evaluation of herbal toothpaste and comparison with commercial herbal toothpastes: An in-vitro study. Int J Ayurvedic Herb Med. 2016;6(3):2266-73.
18. Kumar R, Singh M, Sharma S. Herbal toothpaste: An overview. Int J PharmSci Res.
2020;11(7):1-5.
19. Patil PA, Shiraguppi V, Gokhale N, Kulkarni S. An insight into herbal oral care: Present status and future prospects. Int J Herb Med. 2020;8(3):11-7.
20. Deshmukh P, Telrandhe R, Gunde M. Formulation and evaluation of herbal toothpaste: Compared with marketed preparation. Int J Pharm Drug Anal.2020;8(2): 1-5.
21. Kanoja A, Ghuge P, Holap P, Jagdale A. To formulate and evaluate herbal toothpaste. Int J Pharm Sci. 2023;1 (12):678-689.
22. Pradeep AR, Agarwal E, Naik SB. Clinical and microbiological effects of commercially available dentifrices containing herbal extracts: A randomized clinical trial. J Indian Soc Periodontol. 2012;16(4):524-528.
23. George J, Hegde S, Rajesh KS, Kumar A. The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: A clinic-biochemical study.Indian J Dent Res.
2009;20(4):480-482.
24. Botelho MA, dos Santos RA, Martins JG, Carvalho CO, Paz MC, Azenha C, et al. Efficacy of a mouthrinse based on neem (Azadirachta indica) in the treatment of gingivitis: A double-blind, randomized, controlled trial. J Med Plants Res. 2008;2(11):341-346.
25. Hegde RJ, Joshi S, Rajesh KS. Comparative evaluation of antimicrobial efficacy of herbal and conventional dentifrices against oral microflora. Int J CurrMicrobiol App Sci. 2014;3(1):973-978.
26. Patel PV, Gujjari SK, Patel V. Comparative evaluation of herbal and conventional dentifrices on plaque and gingival health: A clinical trial. J Indian Soc Periodontol. 2012;16(4):524-528.
27. Srisomboon T, Srithavaj T. Inhibitory effects of herbal toothpaste containing Centella asiatica and Garcinia mangostana on oral bacteria: An in vitro study.Southeast Asian J Trop Med Public Health. 2012;43(2):560-567.
28. Lewis WH, Elvin-Lewis MPF. Medical botany: Plants affecting human health.2nd ed.
Hoboken: John Wiley & Sons; 2003.
29. Parkar SM, Parekh SR. Herbal vs conventional dentifrices: A review. J Pharm Sci Res.
2017;9(7): 1022-1026.
30. Grover Hs, Luthra s, Marwah IN, Goyatimicrobial IN. Efficacy of a hertaPedod Prev Dent. 2011;29 (1):22-27.cothpaste on salivary streptococcus miract against long children. J Indian SocCommun. 2012;7(11): 1637-1642.
31. Moghadam| 6(1 1):871- / the pharmacology of clove oil. Nat Prod
32. Pithon MM, Ferraz CD, de Souza RA, de I 6(11):871- iveira DD, NojimaMC. Assessment of antibacterial activity of toothpaste with neem extract against Streptococcus mutans: An in vitro study. d Contemp Dent Pract. 2015;16(11):871-876.
33. Balappanavar Al, Sardana V, Gupta K. The companson of antimicrabial efficacy of herbal and non-herbal dentifrices against Streptococcus mutans: A study. J Dent Hyg.
2013;87(4):212-218.