Volume : 13, Issue : 05, May – 2026
Title:
QUERCETIN-LOADED PLGA NANOSPHERES: FORMATION, CHARACTERIZATION, AND EVALUATION FOR IN VITRO CANCER THERAPY
Authors :
Dr Ch KVLSN Anjan Male, Atul Manjhi, Dr DV Kishore
Abstract :
Quercetin (QU), a natural polyphenolic flavonoid, possesses potent antioxidant and anticancer properties but is limited by poor aqueous solubility and low bioavailability. In this study, we developed quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanospheres using a solid/oil/water (s/o/w) emulsion solvent evaporation technique. The formulation was optimized by varying sonication time and surfactant (PVA) concentration. The optimized nanospheres exhibited a mean diameter of 250.12 ± 10.8 nm, a zeta potential of -37.21 ± 0.48 mV, and an encapsulation efficiency of 78.34 ± 2.5%. Morphological analysis via TEM confirmed spherical particles with smooth surfaces1. These results suggest that PLGA nanospheres are a promising delivery system to enhance the therapeutic efficacy of quercetin in cancer treatment.
Key words : Quercetin, Nanoparticle PLGA Poly (lactic-co-glycolic acid), Flavonoids ,Polymer Emulsion, Sonifier,Cyclodextrin, Hydrophilic
Cite This Article:
Please cite this article in press Ch KVLSN Anjan Male et al., Quercetin-Loaded Plga Nanospheres: Formation, Characterization, And Evaluation For In Vitro Cancer Therapy., Indo Am. J. P. Sci, 2026; 13(05)
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