Volume : 13, Issue : 05, May – 2026

Title:

NANOSPONGES: AN EMERGING APPROACH FOR CONTROLLED AND SUSTAINED DRUG DELIVERY

Authors :

Deepak Jaiswal*, Satkar Prasad

Abstract :

Nanosponges are novel nanoporous drug delivery systems designed to improve the therapeutic efficacy, stability, and controlled release of pharmaceutical agents. These tiny sponge-like structures possess nanosized cavities capable of encapsulating both hydrophilic and lipophilic drugs. Nanosponges are generally prepared using biodegradable polymers and cross-linkers, resulting in a three-dimensional porous network that enhances drug solubility, bioavailability, and targeted delivery. They provide prolonged and controlled drug release, reduce dosing frequency, minimize side effects, and protect unstable drugs from degradation. Various preparation methods such as solvent method, ultrasound-assisted synthesis, and drug loading techniques are employed for nanosponge formulation. Characterization of nanosponges includes particle size analysis, zeta potential, microscopy, thermal analysis, solubility studies, and drug loading efficiency. Nanosponges have shown promising applications in oral, topical, parenteral, pulmonary, antiviral, anticancer, and protein delivery systems. They are also useful in enzyme immobilization, oxygen delivery, and SARS-CoV-2 management. Due to their nanoscale porous structure, high stability, biocompatibility, and controlled release properties, nanosponges represent an advanced and versatile approach in modern pharmaceutical drug delivery systems. Their ability to enhance solubility and site-specific delivery makes them highly valuable for future therapeutic applications.
Keywords: Nanosponges, Novel drug delivery system, Controlled drug release, Targeted drug delivery, Cyclodextrin nanosponges.

Cite This Article:

Please cite this article in press Deepak Jaiswal et al., Nanosponges: An Emerging Approach For Controlled And Sustained Drug Delivery ., Indo Am. J. P. Sci, 2026; 13(05).

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