Volume : 13, Issue : 05, May – 2026
Title:
FORMULATION AND EVALUATION OF A MOUTH ULCER HERBAL GEL USING GUAVA LEAF (PSIDIUM GUAJAVA) EXTRACT
Authors :
Aditya Songara, Anushree Dixit, Shivam Agrawal, Tarawati, Vivek, Arif, Shradha Shende, Dr. Vaishali Rathi
Abstract :
The present study focuses on the formulation and evaluation of a herbal mouth ulcer gel using guava leaf extract obtained from Psidium guajava. Mouth ulcers are common oral lesions associated with pain, inflammation, and discomfort during eating and speaking. Herbal medicines have gained importance due to their safety, effectiveness, and minimal side effects compared to synthetic preparations. Guava leaves are rich in flavonoids, tannins, and phenolic compounds possessing antimicrobial, antiinflammatory, antioxidant, and wound healing properties, making them suitable for the treatment of oral ulcers.
The guava leaves were collected, dried, powdered, and extracted using a hydroethanolic solvent extraction method. The obtained extract was incorporated into a gel base prepared using suitable polymers and excipients. Formulation was prepared by extract and evaluated for physicochemical parameters such as appearance, homogeneity, pH, viscosity, spreadability, extrudability, and drug content.The formulation showed satisfactory physical characteristics with good consistency, acceptable pH, excellent spreadability, and stability. Phytochemical screening of the concentrated extract confirmed the presence of Quercetin (flavonoids), tannins, and saponins. Quercetin is a powerful anti-inflammatory and antioxidant. The gel was formulated using 1% w/v chitosan as a gelling agent, stabilized in a 1% glacial acetic acid medium. The formulated gel was dark in green color and pH ranges from 5.5 to 6.5, ensuring mucosal compatibility. All physicochemical parameters, including spreadability and consistency, were within acceptable pharmaceutical limits. Quercetin combined with a chitosan-based drug delivery system offers an herbal alternative for the treatment of aphthous ulcers. The herbal gel demonstrated significant antimicrobial and healing activity against microorganisms commonly associated with oral infections. The study concludes that guava leaf extract can be effectively formulated into a mouth ulcer gel with promising therapeutic potential. The developed herbal formulation may serve as a safe, economical, and effective alternative for the management of mouth ulcers and oral inflammation.
KEY WORDS: Hydroethanolic solvent, Quercetin, Aphthous ulcer, Psidium Guajava, Chitosan, Anti-inflammatory, Antioxidant, Formulation.
Cite This Article:
Please cite this article in press Aditya Songara et al., Formulation And Evaluation Of A Mouth Ulcer Herbal Gel Using Guava Leaf (Psidium Guajava) Extract., Indo Am. J. P. Sci, 2026; 13(05).
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