Volume : 13, Issue : 05, May – 2026

Title:

FORMULATION AND EVALUATION OF HERBAL EMULGEL CONTAINING RUBIA CORDIFOLIA AND MILLETTIA PINNATA FOR TOPICAL DRUG DELIVERY

Authors :

Shubham Suresh Gulhane*, Dr.Abhijeet V. Shrirao, Dr.Manisha D. Kitukale

Abstract :

Topical drug delivery systems have gained significant importance in modern pharmaceutical sciences due to their ability to provide localized therapeutic action with minimal systemic side effects. Emulgel, a combination of emulsion and gel, represents an advanced topical drug delivery system suitable for both hydrophilic and hydrophobic drugs. The present research work focuses on the formulation and evaluation of a herbal emulgel containing Rubia cordifolia and Millettia pinnata for enhanced topical drug delivery. Different formulations of emulgel were prepared using various concentrations of Carbopol 934, Carbopol 940, and Hydroxy Propyl Methyl Cellulose (HPMC) as gelling agents. The prepared formulations were evaluated for physicochemical parameters such as appearance, pH, homogeneity, spreadability, viscosity, drug content, in vitro drug release, stability studies, and skin irritation potential. FTIR studies confirmed compatibility between herbal extracts and excipients. In vitro drug release studies demonstrated controlled and sustained release behavior, particularly in formulation F5, which showed superior drug release and stability characteristics. Stability studies indicated no significant changes in physical appearance, pH, or drug content during storage. The study concluded that herbal emulgel formulations containing Rubia cordifolia and Millettia pinnata provide effective topical delivery with improved stability, patient compliance, and therapeutic potential for dermatological applications.
Keywords: Herbal Emulgel, Topical Drug Delivery, Rubia cordifolia, Millettia pinnata, Carbopol 934, Carbopol 940, HPMC, Controlled Release, FTIR, Stability Study.

Cite This Article:

Please cite this article in press Shubham Suresh Gulhane et al., Formulation And Evaluation Of Herbal Emulgel Containing Rubia Cordifolia And Millettia Pinnata For Topical Drug Delivery.., Indo Am. J. P. Sci, 2026; 13(05).

REFERENCES:

1. Gupta G. D. Resent advancs in Topical Drug Delivary System, Indo American Journal of pharmaceutical research, 2016:6 page no. 6353-6369.
2. Joshi. B, Singh G, Rana AC, Saini S, Single V. emulgel: a compressive review on the resent advances in a topical drug delivary. International research journal of pharmacy 2011:2(11) p.n. 66-70
3. Dadwal M. Emulgel:A novel approach to topical drug delivery. IntJ Pharm Bio Sci. 2013; 4(1):847-56
4. Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK et al. Recent expansions in an emergent novel drug delivery technology: Emulgel. J Control Release, 2013; 171: 122-32.\
5. Vats S, Saxena C, Easwari T, Shukla V. Emulsion based gel technique: Novel approach for enhancing topical drug delivery of hydrophobic drugs. Int J Pharm Sci Res 2014;3:2277-7873.
6. Yadav S, Mishra M, Tiwari A, Shukla A. Emulgel: A novel approach for enhanced topical drug delivery. Int J Curr Pharm Res 2017;9:15-9.
7. More S, Nandgude T, Poddar S. Vesicles as a tool for enhanced topical drug delivery. Asian J Pharm 2016;10:S196-209.
8. Pant S, Badola A, Baluni S, Pant W. A review on emulgel novel approach for topical drug delivery system. World J Pharm Pharm Sci 2015;4:1728-43.
9. Sonaje S, Gondkar S, Saudagar R. Gellified emulsion: A new born formulation for topical delivery of hydrophobic drugs. World J Pharm Pharm Sci 2013:3:233-51.
10. Rieger M M, Lachman L, Liberman H A, Kanig J L .the theory and practice of industrial pharmacy. 3rd ed. Philadelphia P A:Lea and Febiger 1986 p. no. 502-533
11. Kuller R, Saini S, Seth N, Rana AC. Emulgel: A surrogate approach for topical used hydrophobic drugs. Int J Pharm Sci 2011;1:117-28.
12. Patil SS, Patil PA, Rane SS. Emulgel: a promising dual release system for topical drug delivery. Pharm Nanotechnol. 2023;11(3):191-200.
13. Prajapati A, Mehta M, Shah S. Indomethacin and Azadirachta indica emulgel: synergistic analgesic, anti-inflammatory effects. Indian J Pharm Sci. 2023;85(4):729-38.
14. George E, Thomas S, Mathew J. Formulation and evaluation of neem oil emulgel for anti- dandruff activity. Int J Pharm Investig. 2023;13(1):48-56.