Volume : 13, Issue : 11, November – 2026
Title:
DEVELOPMENT AND INVITRO CHARACTERISATION OF PANTAPROZOLE SODIUM TABLETS BY USING NATURAL DISINTEGRANTS
Authors :
Sridevi*, Neerla Hemesh, Gopularam Shiva Maheshwari, Pamena Anjani, Sandasani Kaveri
Abstract :
The present study was aimed at the formulation and evaluation of Pantoprazole sodium tablets using natural polymers such as Tragacanth and Guar gum by the direct compression method. Pantoprazole sodium is a proton pump inhibitor widely used in the treatment of gastric and duodenal ulcers, gastroesophageal reflux disease, and other acid-related disorders. The objective of the study was to develop a stable tablet formulation with satisfactory physicochemical characteristics and drug release profile.Preformulation studies including organoleptic evaluation, melting point determination, solubility studies, calibration curve preparation, and FTIR compatibility studies were carried out. Pantoprazole sodium was found to be compatible with the selected excipients, as confirmed by FTIR analysis. The powder blends were evaluated for bulk density, tapped density, compressibility index, Hausner ratio, and angle of repose, and all formulations exhibited satisfactory flow properties suitable for direct compression.Four formulations (F1–F4) were prepared using varying concentrations of Tragacanth and Guar gum. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, disintegration time, and in vitro drug release. All formulations complied with pharmacopoeial specifications. The cumulative drug release after 8 hours ranged from 93.22% to 98.12%. Among the formulations, F4 showed the highest drug release of 98.12% and was selected as the optimized formulation.The optimized formulation was subjected to accelerated stability studies at different storage conditions for a period of 90 days. The formulation remained stable without any significant changes in physical appearance or drug release profile.The study concluded that Pantoprazole sodium tablets prepared using Tragacanth and Guar gum exhibited satisfactory physicochemical properties, good drug release characteristics, and acceptable stability. The optimized formulation may serve as a promising oral dosage form for effective drug delivery.
Keywords: Pantoprazole Sodium, Direct Compression, , FTIR, Dissolution Study, Stability Studies.
Cite This Article:
Please cite this article in press Sridevi et al., Development and invitro characterisation of Pantaprozole sodium tablets by using Natural disintegrants.,. Indo Am. J. P. Sci, 2026; 13(11).
REFERENCES:
1. Banker GS and Rhodes CT. Modern Pharmaceutics, Third Edition, revised and expanded. New York: Marcel Dekker Inc. , 2012; 333- 394.
2. Rudnic EM and Kottke MK., Tablet dosage forms In: Banker, GS, Rhodes, CT., (eds.), Modern Pharmaceutics: Third edition revised and expanded. Marcel Dekker Inc., New York, USA, 2003; 333-394.
3. Libermann H and Lachman L. Pharmaceutical Dosage Forms: Tablets, Vol. I to III, Marcel Dekker Inc., N.Y, 85-143.
4. Berenberg, S., New concepts in administration of drugs in tablet form; Formulation and evaluation of a sublingual tablets for rapid absorption, and presentation of an individualized dose administration system, Acta universities upsaliensis, 2003; UPPSALA, 10
5. Maggi L, Ochoa ME, Fasani E, Albini A, Segale L, and Conte U. Photo stability of extended-release matrix formulations. Eur. J. Pharm. Biopharmceutics, 2003, 55; 99-105.
6. Harris D and Robinson JR. Drug delivery via the mucous membranes of the oral cavity. J Pharm. Sci, 1992, 81; 1- 10. 7.
7. Alderborn G, Tablets and compaction. In Aulton, M.E. (Ed), Pharmaceutics. The science of dosage form design, 2nd edition. Churchill Livingstone, New York, 2002; 397-440.
8. Ahmed IS, Nafadi MM, and Fatahalla FA. Formulation of fast-dissolving ketoprofen tablet using freeze-drying in blisters technique. Drug Development and Industrial Pharmacy, 2006; 32; 437-442.
9. Behzadi S. Innovations in Tablet Technology, Recent patents on drug delivery and formulations, 2008; 209-230.
10. Gupta A, Bilandi A, Kataria M K, and Kahatri N. Tablet coating techniques: Concepts and recent trends. International Research Journal of Pharmacy, 2012, 3; 50-58. 240
11. Neelam DK, Prafulla SC, Rajesh JO, Sandip SK, and Rishikesh VA. Innovations in tablet coating technology: A review. International journal of applied biology and pharmaceutical technology; 2011, 2; 214-218.
12. Cole G. Pharmaceutical Coating Technology, Taylor and Francis Ltd, 2009; 1- 5.
13. Porter C. Coating of Pharmaceutical Solid-dosage forms, Pharm. Tech., 1980, 4; 66.
14. Venkateswara RB, Navaneetha K, Rashmitha RB. Tablet Coating Industry Point View- A Comprehensive Review. IJPBS, 2013; 3: 248-261 15.
15. Skultety, PF, Rivera D, Dunleavy J, and Lin CT. Drug Dev. Ind. Pharm, 1988, 14; 617.
16. Atul MM, Processing and equipment considerations for aqueous coatings, in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, Third Edition, Edited by James W. McGinity , Linda A. Felton, Informa Healthcare USA, Inc. New York, 2008.