Volume : 13, Issue : 11, November – 2026
Title:
DEVELOPMENT AND EVALUATION OF IBUPROFEN LOADED CUBOSOMES FOR ENHANCED ORAL BIOAVAILABILITY
Authors :
Ragipati Suneetha, Degulavadi Sushmitha,Moluguri Uday Kumar, Mareedu Uma,Sama Vagdevi , Polu Vaishnavi
Abstract :
The present study was undertaken to formulate and evaluate Ibuprofen-loaded cubosomes as a novel nanocarrier system for enhanced drug delivery and sustained drug release. Drug-excipient compatibility studies were carried out using FTIR spectroscopy, which confirmed the absence of any significant interaction between Ibuprofen and the selected excipients.The prepared cubosomal formulations were characterized for particle size, zeta potential, entrapment efficiency, and in vitro drug release. The particle size of the formulations ranged from 169 to 183 nm, while zeta potential values ranged from -25 to -30 mV, indicating good physical stability of the cubosomal dispersions. Entrapment efficiency was found to be in the range of 79.80% to 85.92%, demonstrating efficient incorporation of the drug within the cubosomal matrix.In vitro drug release studies revealed sustained release of Ibuprofen from all formulations over a period of 8 hours. Among the developed formulations, F4 exhibited the highest cumulative drug release (98.52%), maximum entrapment efficiency (85.92%), smallest particle size (169 nm), and highest zeta potential (-30 mV), indicating superior formulation characteristics. Stability studies conducted on the optimized formulation (F4) under accelerated storage conditions for three months showed no significant changes in drug release behavior, confirming the stability of the formulation.
Keywords: Ibuprofen, Cubosomes, Controlled Drug Delivery, Glyceryl Monooleate, Poloxamer 407, Entrapment Efficiency, Sustained Release, Nanocarrier System.
Cite This Article:
Please cite this article in press Ragipati Suneetha et al., Development And Evaluation Of Ibuprofen Loaded Cubosomes For Enhanced Oral Bioavailability.,. Indo Am. J. P. Sci, 2026; 13(11).
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