Volume : 13, Issue : 11, November – 2026

Title:

FORMULATION AND CHARACTERIZATION OF METHIMAZOLE-LOADED TRANSDERMAL PATCHES FOR CONTROLLED SYSTEMIC DELIVERY

Authors :

Bojja Prakarsha, I.Nagaraju, I., Dr.G.S.Valluri, G Vijaya Kumar

Abstract :

Methimazole is an antithyroid agent widely prescribed for the management of hyperthyroidism; however, conventional oral administration is associated with frequent dosing, variable bioavailability, and systemic adverse effects. The present study aimed to formulate and characterize methimazole-loaded transdermal patches for controlled systemic delivery to improve therapeutic efficacy and patient compliance. Prior to formulation, pre-formulation studies were performed to evaluate the physicochemical properties of methimazole, including organoleptic characteristics, solubility profile, melting point, partition coefficient, drug identification, and compatibility with selected polymers using Fourier Transform Infrared (FTIR) spectroscopy. The transdermal patches were prepared by the solvent-casting technique using suitable film-forming polymers, plasticizers, and permeation enhancers.
The formulated patches were characterized for Physio chemical and pharmaceutical properties, including appearance, thickness, weight uniformity, folding endurance, tensile strength, percentage moisture content, moisture uptake, drug content uniformity, surface pH, and flatness. In vitro drug release studies were carried out using a suitable diffusion medium, while ex vivo permeation studies were performed across biological membrane models to assess transdermal drug transport. Release kinetics were analysed using mathematical models to determine the mechanism of drug release. The optimized methimazole transdermal patch demonstrated acceptable physio chemical properties, uniform drug distribution, sustained drug release, satisfactory permeation characteristics, and good stability throughout the study period. The findings suggest that the developed transdermal system has the potential to provide controlled systemic delivery of methimazole, reduce dosing frequency, and enhance patient adherence, making it a promising alternative to conventional oral therapy for the long-term management of hyperthyroidism.
Keywords: Methimazole, Transdermal Patch

Cite This Article:

Please cite this article in press Kummari Ashwini et al., Evaluation Of Analgesic Activity Of Methanol Extracts Of Zingiber Officinale In Male Wistar Rats.,. Indo Am. J. P. Sci, 2026; 13(11).

REFERENCES:

1. Chien Y.W. “Novel Drug Delivery Systems”, 2nd Edition, Drugs And Pharmaceutical Sciences, Volume-50, Marcel Dekker, Inc.
2. Finnin B C, Morgan T M, Trasndermal penetration. J Pharm Sci. Oct 1999;88 (10):955-958.
3. Allen L V, Popovich N G, Ansel H C, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems, 8th Edition, Lippincott Williams & wilkins, 2005:298- 315.
4. Barry B. Transdermal Drug Delivery. In Ed: Aulton M E, Pharmaceutics: The Science of Dosage Form Design, Churchill Livingston. 2002:499-533
5. Cleary G W, Transdermal controlled release systems. Medical Applications of Controlled Release. 1:203-251.
6. Vyas S P, Khar R K, Controlled Drug Delivery: Concepts and Advances, Vallabh Prakashan, 1st Edition. 2002:411-447.
7. Tortora G, Grabowski S. The Integumentary system. In: Principles of Anatomy and Physiology. 9th edition. John Wiley and Sons Inc. 150-151.
8. Wilson K J W, Waugh A. Eds, “Ross And Wilson: Anatomy And Physiology In Health And Illness”, 8th Edition, Churchill Livingstone. 1996:360-366.
9. Thomas J. Franz. Transdermal delivery in treatise on controlled drug delivery 3rd ed. New York: Marcel Dekker Inc; 1991.
10. Heather A.E. Benson, Transdermal Drug Delivery: Penetration Enhancement Techniques, Current Drug Delivery, 2005, 2, 23-33.
11. P.Loan Honeywell-Nguyen, Joke A. Bouwstra, Vesicles as a tool for Transdermal and Dermal Delivery, Drug Discovery Today: Technologies, 2005, 2(1), 67-74.
12. Ramesh Gannu, Y. Vamshi Vishnu, V. Kishan, Y. Madhusudan Rao, “Development of Nitrendipine Transdermal Patches: In vitro and Ex-vivo Characterization”, Current Drug Delivery, 4 (2007), 69-76.
13. J.R.D.Gupta, R.Irchiayya N.Garud. “Formulation and evaluation of matrix type transdermal patches of Glibenclamide”, International Journal of Pharmaceutical Sciences Development and Research, 1(1), (2009), 46-50.
14. Kenneth A. Walters, michael s. Roberts; Dermatological and Transdermal Formulatons; 204-241.
15. Oh SY, Jeong SY, Park TG, Lee JH. Enhanced transdermal delivery of AZT (Zidovudine) using iontophoresis and penetration enhancer. J Control Release. 1998 Feb 12; 51(2-3):161-8.
16. Inayat Bashir Pathan1, C Mallikarjuna Setty; Chemical Penetration Enhancers for Transdermal Drug Delivery Systems; Tropical Journal of Pharmaceutical Research, April 2009; 8 (2): 173-179
17. Ashok K. Tiwary, Bharti Sapra and Subheet Jain, Innovations in Transdermal Drug Delivery: Formulations and Techniques, Recent Patents on Drug Delivery & Formulation 2007, 1, 23-36.