Volume : 13, Issue : 09, September – 2026
Title:
COUMARIN DERIVATIVES AS PROMISING THERAPEUTIC AGENTS AN UPDATED REVIEW
Authors :
Mallikarjun H, Kartik Havale, Sandhya D. Chinnamulagund*, Tabasum Killedar, V. H. Kulkarni, Shrinivas D. Joshi
Abstract :
Coumarin (2H-chromen-2-one) is a naturally occurring benzopyrone compound that has attracted considerable attention because of its wide range of biological activities and its importance in medicinal chemistry. Owing to its versatile chemical structure, coumarin serves as a valuable scaffold for the development of numerous therapeutically active compounds. This review provides an overview of the physicochemical and spectroscopic properties of coumarin, along with the major synthetic methods, including the Perkin, Pechmann, Kostanecki–Robinson, and Claisen rearrangement reactions. The characteristic IR and 1H NMR spectral features used for the identification and structural confirmation of coumarin are also discussed. In addition, recent advances in the synthesis and biological evaluation of coumarin derivatives are summarized, highlighting their antimicrobial, antibacterial, antifungal, anti-tubercular, antioxidant, and anticancer activities. The review also discusses how structural modifications of the coumarin nucleus influence biological activity and improve therapeutic potential. Furthermore, selected commercially available coumarin derivatives and their pharmaceutical significance are briefly described. Overall, this review highlights the growing importance of coumarin as a versatile heterocyclic scaffold and its continued potential in the discovery and development of new bioactive molecules.
Keywords: Coumarin, Heterocyclic compounds, Medicinal chemistry, Drug discovery, Biological activity.
Cite This Article:
Please cite this article in press Sandhya D C et al., Coumarin Derivatives As Promising Therapeutic Agents An Updated Review.,. Indo Am. J. P. Sci, 2026; 13(10).
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