Volume : 13, Issue : 10, October – 2026

Title:

VALIDATED RP-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ESTIMATION OF RANITIDINE AND METOCLOPRAMIDE IN BULK AND TABLET DOSAGE FORM

Authors :

Dharavath Ahalya*, Dr.K. Hariprasad

Abstract :

A validated, precise, and accurate High-Performance Liquid Chromatography (HPLC) method was developed for the simultaneous estimation of Ranitidine and Metoclopramide in bulk and tablet dosage forms. The chromatographic analysis was performed using an X-Bridge C18 column (4.6 × 150 mm, 5 µm) at ambient temperature, with a mobile phase consisting of Methanol and Water (65:35 v/v). The flow rate was maintained at 1 mL/min, and detection was carried out at a wavelength of 260 nm. The injection volume was 10 µL, and the total run time was 14 minutes. The method provided effective resolution of both analytes with sharp and distinct peaks, indicating successful separation. Validation of the method was conducted as per ICH guidelines, demonstrating excellent linearity, accuracy, precision, specificity, and robustness. The proposed method is suitable for routine quality control and simultaneous quantification of Ranitidine and Metoclopramide in pharmaceutical preparations.
Keywords: RP-HPLC, Ranitidine and Metoclopramide, X-Bridge C18 column, simultaneous estimation, validation.

Cite This Article:

Please cite this article in press Dharavath Ahalya et al Validated Rp-High Performance Liquid Chromatography Method For Estimation Of Ranitidine And Metoclopramide In Bulk And Tablet Dosage For.,. Indo Am. J. P. Sci, 2026; 13(10).

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