Volume : 13, Issue : 10, October – 2026

Title:

SYNTHESIS, CHARACTERIZATION AND EVALUATE THE BIOLOGICAL ACTIVITY OF SOME OF SUBSTITUTED IMIDAZOLE DERIVATIVES.

Authors :

Kunapuli Venkatasai Sushumna*,G.Swetha Reddy

Abstract :

Broadly the following conclusion could be drawn from the results of these investigations.
Synthetic work of the studies could go positively as per the planning and as such in all the reactions carried out. The expected compounds alone could be obtained.
Newly synthesized compounds were characterized by TLC, IR, ¹H-NMR and Mass spectral analysis.
New imidazole derivatives showed promising antimicrobial activity. Compounds Methyl and Fluorine imidazole derivatives were found to be the more potent antibacterial activity respectively towards gram positive (Micrococcus luteus) and gram negative (klebsiella pneumonia)
New imidazole derivatives showed promising antioxidant activity. Compounds (R=F) & (R= CH3) were found to be more potent antioxidant compounds among the all-test compounds.

Cite This Article:

Please cite this article in press Kunapuli Venkatasai Sushumna et al., Synthesis, Characterization And Evaluate The Biological Activity Of Some Of Substituted Imidazole Derivatives.,. Indo Am. J. P. Sci, 2026; 13(10).

REFERENCES:

1. Narayana, Jayaram Lakshmaiah, and Jyh-Yih Chen. “Antimicrobial peptides: possible anti-infective agents.” Peptides 72 (2015): 88-94.
2. Choudhary, Alka N., and Vijay Juyal. “Synthesis of chalcone and their derivatives as antimicrobial agents.” International journal of pharmacy and pharmaceutical Sciences 3.3 (2011): 125-128.
3. Dan, Wenjia, and Jiangkun Dai. “Recent developments of chalcones as potential antibacterial agents in medicinal chemistry.” European journal of medicinal chemistry 187 (2020): 111980.
4. Karthikeyan, Chandrabose, et al. “Advances in chalcones with anticancer activities.” Recent patents on anti-cancer drug discovery 10.1 (2015): 97-115.
5. Ankit Mittal, Vinod Kumar Vashistha, Dipak Kumar Das. (2022) Recent advances in the antioxidant activity and mechanisms of chalcone derivatives: a computational review. Free Radical Research 0:0, pages 1-20.
6. Ouyang, Yang, et al. “Chalcone derivatives: Role in anticancer therapy.” Biomolecules 11.6 (2021): 894.
7. Chu, Wen-Chao, et al. “Synthesis and antibacterial evaluation of novel cationic chalcone derivatives possessing broad spectrum antibacterial activity.” European journal of medicinal chemistry 143 (2018): 905-921.
8. Chen, Hong, et al. “Bis-chalcone derivatives derived from natural products as near- UV/visible light sensitive photoinitiators for 3D/4D printing.” Materials Chemistry Frontiers 5.2 (2021): 901-916.
9. Hedaitullah, Md & Ramanpreet, Walia & Khalid, Iqbal & Balwan, Singh & Husain, Asif. (2014). Pyrazoline synthesis through a chalcone intermediate. Int. J. Drug Reg. Affairs. 2. 59-62. 10.22270/ijdra.v2i4.153.
10. Jo S, Kim H, Kim S, Shin DH, Kim M‐S (2019) Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors. Chemical Biology & Drug Design 94: 2023– 2030.