Volume : 13, Issue : 10, October – 2026
Title:
DESIGN, SYNTHESIS AND EVALUATION OF NOVEL 2-(1-BENZYL-2-OXOINDOLIN-3-YLIDENE)-N-PHENYLHYDRAZINECARBOXAMIDE DERIVATIVES AS ANTI CANCER AGENTS
Authors :
Pathireddy Soumya*, Dr. K. Hariprasad
Abstract :
Novel 2-(1-benzyl-2-oxoindolin-6-substituted-3-ylidene)-n-phenylhydrazinecarboxamide derivatives are an important class of nitrogen containing heterocyclic’s and were identified as the most active and potent classes of compounds with wide range of biological and pharmacological activities. A new series of 2-(1-benzyl-2-oxoindolin-3-ylidene)-n-phenylhydrazine carboxamide derivatives were characterized by spectral data and evaluated for Anticancer activity, Anti-Alzheimer’s activity and anti-microbial activity. The compounds 7d, 7i, were found to be good inhibitors of HELa and MCF-7. Most of the compounds inhibited HELa and MCF-7 with the IC50 values, ranging from 0.78µM 7.64 µM. Amongst them, compounds 7d, 7i with fluoro substituted indole exhibited strongest inhibitory activity against HELa and MCF-7 with IC50 1.91±0.02 µM, 0.92±0.03 µM for 7d and 1.31±0.02 µM, 0.78±0.33 7i respectively, when compared to standard Cisplain with IC50 of 0.65±0.02 µM and 0.47±0.02. The compound 7i with fluoro substituted indole containing Schiff base showed potent anti-Alzheimer’s activity with IC50values 0.92±0.13, 1.01±0.12 µM against AChE and BuChE respectively when compared to Standard drug donepazil showed IC50 0.51±0.06 and 0.31±0.04μM against AChE and BuChE respectively.7i ,7m & 7n showing potent activity for different strains of bacteria ranging from 10mm to 14mm when compared to ciprofloxacin 13- 16mm. Thus, these Novel 2-(1-benzyl-2-oxoindolin-3-ylidene)-n-phenylhydrazine carboxamide derivatives have emerged as new cancer and AChE and BuChE inhibitors and showing anti microbial activity for further exploitation as anti-cancer and anti-Alzheimer’s agents, anti bacterial agents. Docking studies of all the molecules disclosed close hydrogen bond interactions with in the binding site.
Keywords: Alzheimer’s disease, anti-cancer, cholinesterase inhibitor, Anti-bacterial agents
Cite This Article:
Please cite this article in press Pathireddy Soumya et al., Design, Synthesis And Evaluation Of Novel 2-(1-Benzyl-2-Oxoindolin-3-Ylidene)-N-Phenylhydrazinecarboxamide Derivatives As Anti Cancer Agents.,. Indo Am. J. P. Sci, 2026; 13(10).
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