Volume : 13, Issue : 10, October – 2026
Title:
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CLONAZEPAM PREPARED BY SUBLIMATION METHOD
Authors :
Meesala Yogitha, Dr. L. Harikiran
Abstract :
The objective of the present study was to formulate and evaluate mouth dissolving tablets (MDTs) of Clonazepam using the sublimation method to enhance patient compliance, provide rapid onset of action, and improve bioavailability. Tablets were prepared by direct compression incorporating sublimating agents to create porosity and facilitate faster disintegration. The prepared formulations were evaluated for pre-compression parameters such as angle of repose, bulk density, tapped density, and compressibility index, as well as post-compression parameters including hardness, friability, weight variation, wetting time, drug content uniformity, disintegration time, and in vitro dissolution. All pre-compression and post-compression parameters were found to be within pharmacopeial limits, confirming the suitability of the formulations. Among the different batches, formulation F9 was identified as the optimized formulation, showing rapid disintegration and an in vitro drug release of 99.84% within 60 minutes, indicating its effectiveness in delivering Clonazepam quickly.
The study concludes that the sublimation method is a simple and effective technique for developing mouth dissolving tablets of Clonazepam, providing a patient-friendly dosage form especially useful for paediatric, geriatric, and dysphagic patients.
Keywords: Clonazepam, Mouth Dissolving Tablets
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Cite This Article:
Please cite this article in press Meesala Yogitha et al., Formulation And Evaluation Of Mouth Dissolving Tablets Of Clonazepam Prepared By Sublimation Method.,. Indo Am. J. P. Sci, 2026; 13(10).
REFERENCES:
1. Rangasamy, M., Oral disintegrating tablets: A future compaction. Int. J. Pharm. Res. Dev., 1(10), 1-10 (2009).
2. Debjit, B., Chiranjib, B., Krishnakanth., Pankaj., Margret, R., Fast Dissolving Tablets: An Overiew. Journal. Chem. Pharm. Research., 1(1), 163 – 177 (2009).
3. Metkari VB1,* Kulkarni LV1, Patil PS1, Jadhav PA1, Jadhav PH1, Yadav PS1. Formulation and Evaluation of Fast Disolving Tablets of Carbamazepine Using Solid Dispersion.journal.2014:02(1);47-49.
4. Pinkal Prajapati and Jitendra Patel. formulation development and evaluation of fast dissolving tablets of cyproheptadine hydrochloride. Pharma Science Monitor, 2014:5(2);247-253.
5. Rajasekhar Reddy*.formulation and in vitro evaluation of temazepam oral dispersible tablets . Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry. 2(1), 2014, 1 -8.
6. Santhosh R Iyer*, R. Sivakumar, P. Siva and CI. Sajeeth. formulation and evaluation of fast dissolving tablets of Risperidone solid dispersion. international journal of pharmaceutical, chemical and biological SCIENCES.journal.2013: (2);388-397.
7. Praveen khirwadkar *, Kamlesh Dashora. formulation and evaluation of fast dissolving tablets Atenolol. Journal of Chemical and Pharmaceutical Sciences.2013;113-119.
8. K. Venkatesh, N. G. Raghavendra Rao*, Gampa Vijaya Kumar, C.Kistayya PREPARED BY SOLID DISPERSION METHODS, International Journal of Biopharmaceutics. 2013;4(2):96-10.
9. Ravi kiran Sahu*, Dipti Ranjan Pany Dipak Kumar Pati, Arun Kumar Dash, Design and Evaluation of Fast Disintegrating Tablets of Metformin Effervescence method. International Journal of Pharmaceutical and Biological Archives 2011; 2(4):1253-1257.
10. Nagendrakumar D(2013), Keshavshetti GG, Pratibha. design and evaluation of fast dissolving tablets of metoclopramide hydrochloride using synthetic and natural super-disintegrants. unique journal of pharmaceutical and biological sciences,2013:(2): 55-70.