Volume : 13, Issue : 09, September – 2026
Title:
INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF COMBINED EXTRACTS OF BETEL LEAF AND TURMERIC IN RATS
Authors :
P. Reena Sowmya*, Medipalli Malavika, S. Srikaran, Shaik Naseer, Md. Ashwaq
Abstract :
Inflammation and oxidative stress are closely interlinked pathological processes involved in the progression of various acute and chronic diseases. The present study was designed to evaluate the anti-inflammatory and antioxidant potential of combined ethanolic extracts of Piper betle (betel leaf) and Curcuma longa (turmeric) in carrageenan-induced paw edema in Wistar rats. The extracts were administered orally at doses of 200 mg/kg and 400 mg/kg, and their effects were compared with the standard drug Indomethacin (10 mg/kg). Acute inflammation was induced using carrageenan injection into the sub-plantar region of the rat paw. Paw volume was measured at regular intervals to assess anti-inflammatory activity. Antioxidant parameters including superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and malondialdehyde (MDA) were estimated in tissue homogenates to evaluate oxidative stress status. Results revealed that carrageenan significantly induced paw edema along with oxidative stress, evidenced by decreased SOD, CAT, and GSH levels and increased MDA levels. Treatment with the combined plant extract produced a dose-dependent reduction in paw edema and significantly improved antioxidant enzyme levels while reducing lipid peroxidation. The higher dose (400 mg/kg) showed effects comparable to the standard drug. The findings suggest that the combined extract of Piper betle and Curcuma longa possesses significant anti-inflammatory and antioxidant properties, which may be attributed to the presence of bioactive phytoconstituents such as flavonoids, phenols, tannins, and terpenoids. The study supports the potential use of this combination as a natural therapeutic agent against inflammation-associated oxidative stress.
Cite This Article:
Please cite this article in press P Reena Sowmya et al., Inflammatory And Antioxidant Potential Of Combined Extracts Of Betel Leaf And Turmeric In Rats.,. Indo Am. J. P. Sci, 2026; 13(09).
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