Volume : 13, Issue : 09, September – 2026

Title:

FORMULATION AND IN-VITRO EVALUATION OF GASTRO-RETENTIVE DRUG DELIVERY SYSTEM FOR LEVODOPA

Authors :

P. Keziakereen*, B.Harika, Md Sameena Begum, Ratnam Sarayu, Syed Misbah Hussain, T. Pavithra

Abstract :

The main purpose of the study was to develop Levodopa floating tablets via non-effervescent technique using various polymers by direct compression. Before compression, the particulate powdered mixture was evaluated for pre-compression parameters. Compatibility among the formulation components was assessed by FTIR studies. FTIR studies revealed no interaction between the drug and polymers used. The prepared Levodopa floating tablets were evaluated for post-compression parameters, swelling index, floating lag time, in vitro buoyancy studies, and in vitro drug release studies. Optimized formulation (F2) revealed that tablet was constantly floating in the stomach region, thereby indicating improved gastric retention time for more than 8 hr. Consequently, all the findings and outcomes have showed that developed Levodopa floating tablets could be effectively used for floating drug delivery system.
Keywords: Levodopa, Natural Polymers, FTIR studies, Direct compression technique, In vitro drug release studies.

Cite This Article:

Please cite this article in press P. Keziakereen et al., Formulation And In-Vitro Evaluation Of Gastro-Retentive Drug Delivery System For Levodopa.,. Indo Am. J. P. Sci, 2026; 13(09)..

REFERENCES:

1. Bagherwal A, Patidar DK, Sharma P. Formulation and evaluation of floating tablets of ciprofloxacin hydrochloride. Int J Comp Pharma 2010;1:1-4.
2. Kumar R. Development and in-vitro evaluation of sustained release floating matrix tablets of metformin hydrochloride. Int J Pharm Sci Res 2010;1:96-101.
3. Chodavarapu NP, Yendluri RB, Suryadevara H, Reddy P, Chhatoi P. Formulation and evaluation of abelmoschusesculentus mucilage based metformin hydrochloride floating matrix tablets. Int J Pharm Tech 2011;3:2725-45.
4. Kshirsagar RV, Jain V, Wattamwar S. Effect of different viscocity grade HPMC polymer on gastroretantive drug delivery of metformin hydrochloride. Int J Appl Pharm 2009; 1:44-50.
5. Chandiran IS, Kumar BP, Narayan V. Formulation and in-vitro evaluation of floating drug delivery system for salbutamol sulphate. Int J Pharm Biomed Sci 2010; 1(1):12-15.
6. Hu L, Li L, Yang X, Liu W, Yang J, Jia Y, et al., Floating matrix dosage form for dextromethorphan hydrobromide based on gas forming technique. In-vitro and in-vivoevalvation healthy volunteers. Eur J Pharm Sci 2011;42:99-105.
7. Raju BD, Sreenivas R, Varma MM. Formulation and evaluation of floating drug delivery system of metformin hydrochloride. J Chem Pharm Res 2010;2(2):274-78.
8. Senthilkumar SK, Jaykar B, Kavimani S. Formulation and evaluation of gastroretentive floating drug delivery system of rabeprazole sodium. Int J Biopharm 2011;2(2):57-62.
9. Mohammed MS. Formulation and in-vitro evaluation of sustained release intragastric tablets of propranolol hydrochloride using natural polymer. J Pharm Biomed Sci 2011;10(10):1-10.
10. Goole J, Vanderbist F, Amighi K. Development and evaluation of new multi-unit levodopa sustained-release floating dosage forms. Ind J Pharm 2007;334:35-41.
11. Sauzet C, Bruno CM, Nicolas M, Kister J, Piccerdle P, Prinderre P. An innovative floating gastro retentive dosage system. Formulation and in-vitro evaluation. Int J Pharm 2009;378:23-29.
12. Abrahamsson, B., Alpsten, M., Hugosson, M., Jonsson, U.E., Sundgren, M., Svenheden, A., Tölli, J., 1993. Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets. Pharm. Res. 10, 709-714.
13. Agrawal, A.M., Manek, R.V., Kolling, W.M., Neau, S.H., 2003. Studies on the interaction of water with ethylcellulose: effect of polymer particle size. AAPS Pharm. Sci. Tech. 4, E60.
14. Bhongiri B, Ramachandran V, Kumar RS. Preformulation studies of S-Equol. Journal of Pharmaceutical Negative Results. 2022;13(4):1020-9.
15. Babu MK, Hasan N, Bhongiri B, Patel JR, Abirami A, Sharma S, Sarvadnya AA, Sindhu YR, ul Firdaus J. Creation and Improvement of Nanoparticulate Drug Delivery Methods for Penetration of the Blood-Brain Barrier. Journal of Neonatal Surgery. 2025;14(3).
16. Alvisi, V., Gasparetto, A., Dentale, A., Heras, H., Felletti-Spadazzi, A., D’Ambrosi, A., 1996. Bioavailability of a controlled release formulation of ursodeoxycholic acid in man. Drugs Exp. Clin. Res. 22, 29-33.
17. Amaral, M.H., Lobo, J.M., Ferreira, D.C., 2001. Effect of hydroxypropyl methylcellulose and hydrogenated castor oil on naproxen release from sustained-release tablets. AAPS Pharm. Sci. Tech. 2, E6.
18. Andrews, G.P., Laverty, T.P., Jones, D.S., 2009. Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm. 71, 505-518.