Volume : 13, Issue : 09, September – 2026
Title:
DEVELOPMENT OF ALOE VERA EXTRACT LOADED LIPOSOMES FOR SKIN HYDRATION AND WOUND HEALING
Authors :
Payal Jain*, M. Sindhuja, B. Venu Gopal, S. Rohini, Shaik Majid
Abstract :
The present study aimed to formulate and evaluate Aloe vera extract-loaded liposomes to enhance the therapeutic efficacy and controlled delivery of Aloe vera for topical applications. FTIR analysis confirmed the compatibility of Aloe vera extract with the selected lipids and excipients, as no significant changes in characteristic peaks were observed. The prepared liposomal formulations were evaluated for particle size, morphology, entrapment efficiency, and drug release behavior. SEM analysis revealed spherical vesicles with uniform morphology. Among the formulations, F2 exhibited the smallest particle size of 179 nm, while formulation F3 showed the highest drug entrapment efficiency of 85.19%. In vitro drug release studies demonstrated sustained drug release over a period of 8 hours, with formulation F3 exhibiting the highest cumulative drug release of 98.51%. The optimized formulation (F3) was further subjected to stability studies under various storage conditions for three months. The formulation showed no significant changes in its physical characteristics or drug release profile, retaining more than 95% drug release throughout the study period, indicating good stability. The results suggest that Aloe vera extract-loaded liposomes are a promising vesicular drug delivery system capable of enhancing drug encapsulation, providing sustained release, and maintaining formulation stability. Therefore, the optimized liposomal formulation may serve as an effective carrier for the topical delivery of Aloe vera extract.
Keywords: Aloe vera, Liposomes, Vesicular Drug Delivery System, Entrapment Efficiency, In Vitro Drug Release, Stability Studies, Topical Delivery.
Cite This Article:
Please cite this article in press Payal Jain et al., Development Of Aloe Vera Extract Loaded Liposomes For Skin Hydration And Wound Healing.,. Indo Am. J. P. Sci, 2026; 13(09).
REFERENCES:
1. Benita S. Microencapsulation Method and Industrial Application, Drug and The Pharmaceutical sciences. Vol.73 2002. p. 213.
2. Fuji G. Vesicles, Realization of the Drug Delivery Concept. Vol.62 1996. New York p. 491-495.
3. Bangham AD, Standish MM. Diffusion of univalent ions across the lamella of swollen Phospholipids. J. Mol. Biol. 1965; 13: 238-252.
4. Vyas SP, Khar RK. Targeted and controlled Drug Delivery, Novel Carrier system, CBS Publishers and distributors. 2002. p. 249.
5. Gregoriadis G. Liposome technology, Liposome preparation and related techniques, 3rd edition, vol. l 2007. p. 21.
6. Singh S, Gulati M. Advances in liposomal therapeutics, Targeting of drugs to lipid bilayer in liposomes: an approach for the success of liposomes as delivery systems. CBS Publishers and distributors. New Delhi. 2001. p. 4-34.
7. Scherphof G, Morselt H, Regts J. The involvement of the lipid phase transition in the plasma-induced dissolution of multilamellar phosphatidylcholine vesicles. Biochem. Biophys. Acta.1979;556:196–207.
8. Jain NK. Controlled and novel drug Delivery, CBS Publishers and distributors.2002. p. 305,326,330.
9. Bangham AD. Techniques in life Science, lipid membrane biochemistry. Elsevier scientific publications. Ireland. 1982 p.1-25.
10. Drummond DC, Meyer O, Hong K. Pharmacokinetic study of liposome encapsulated drug. Pharmacological reviews 1999; 51(4): 691-743.11.
11. Lasic DD. Stealth liposomes,Microencapsulation Method and Industrial Applications. Vol. 73 1996 p. 297-311.
12. Crommelin DJ, Schreier H. Liposomes, Colloidal Drug Delivery Systems. 1996 p. 73-157.
13. Liu R, Cannon JB, Li Y. Liposomes in Solubilization. Water Insoluble Drug FormulationCRC Press, New York. 2000; 355-358.
14. Patel HM, Ryman BR. Systemic and Oral administration of liposomes. Physical Structure to therapeutic applications 1981; 409-439.
15. Jaggi M, Khar RK. Liposomes as Drug Carriers. Indian Drugs 1989; 27(8):404.
16. Krensky AM, Strom TB. Immunomodulators: Immunosuppressive agents, Tolerogens and Immunostimulants. Goodman and Gilman’s The Pharmacological Basis of TherapeuticsLimbird LE (Ed.) 10th Ed, 2001 p. 1466-1480.