Volume : 13, Issue : 09, September – 2026
Title:
SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS: ADVANCES AND EMERGING TRENDS
Authors :
Shiva Sree Chalasani*, Karthik Reddy Alla, Nafeez Syed, Harika Naganaboina
Abstract :
Most modern medicines don’t dissolve well in water, which often leads to poor absorption after they’re taken. This is especially typical with lipophilic medicines—drugs that stick to fat more than water. A solid solution to this limitation in lipid-based drug delivery is the Self-Micro emulsifying Drug Delivery System, or SMEDDS. The blend of oil, surfactant, co-surfactant, and drug in equal proportions is called SMEDDS. When swallowed, it mixes with stomach fluids and instantly forms a tiny oil-in-water mixture. This method boosts the drug’s surface area, making it more soluble—and that helps it absorb better in the gut and become more available in the body. SMEDDS work especially well for drugs that don’t dissolve easily in water or break down poorly. They usually come in soft or firm gelatin capsules. Surfactants like Tween 80 help medications cross the intestinal barrier by boosting absorption through better membrane penetration. A lot of newly discovered drugs don’t dissolve well in water, and that’s holding back progress in modern medicine. That’s why SMEDDS are a great way to boost the solubility, dissolution, absorption, and bioavailability of poorly soluble drugs.
Key Words: SMEDDS, Poorly water-soluble drugs, Lipophilic drugs, Solubility enhancement, Dissolution enhancement, Microemulsion, Lipid-based drug delivery, Drug absorption
Cite This Article:
Please cite this article in press Shiva Sree Chalasani et al., Self-Microemulsifying Drug Delivery Systems: Advances And Emerging Trends.,. Indo Am. J. P. Sci, 2026; 13(09).
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