Volume : 13, Issue : 10, October – 2026
Title:
DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF ROSIGLITAZONE MALEATE
Authors :
Porika Sunil*, Mohit Chaturvedi
Abstract :
The aim of present study is development and characterization of mucoadhesive microspheres of Rosiglitazone maleate and Empaglifozin by combine the potential advantages of mucoadhesion with controlled drug. Rosiglitazone maleate is an anti diabetic drug precisely controls the blood glucose level in diabetic patient and Empaglifozin works by blocking the sodium-glucose co-transporter-2 (SGLT2) in the kidneys. This reduces the amount of glucose reabsorbed into the blood and increases the amount of glucose excreted in the urine. Mucoadhesive microspheres of Rosiglitazone maleate and Empagliflozin are prepared by using various ratios of carbopol-934, sodium carboxymethyl cellulose and sodium alginate by emulsification solvent evaporation techniques. Various preformulation studies are done to confirm the purity, pharmacopoeial standards and for physicochemical characterisation of the drugs. Six formulations for each drug are prepared using different ratios of carbopol-934, sodium carboxymethyl cellulose and sodium alginate. These formulations are assigned for reproducibility with respect to % yield, particle size, % drug entrapment, % mucoadhesion and % drug release of microspheres. The formulation F1 containing sodium carboxymethyl cellulose showed reproducible results and the best mucoadhesive profile with good surface morphology. Among all the formulations of microspheres, formulation F1 containing sodium carboxymethyl cellulose showed best results, demonstrated the best sustained release efficacy out of all the microsphere formulations
Key Words: mucoadhesive microspheres, Rosiglitazone maleate, Empaglifozin, sodium-glucose co-transporter-2 (SGLT2), carbopol-934.
Cite This Article:
Please cite this article in press Porika Sunil et al., Development And Characterization Of Mucoadhesive Microspheres Of Rosiglitazone Maleate.,. Indo Am. J. P. Sci, 2026; 13(10).
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